Sisebenzisa iikuki ukuphucula amava akho.Ngokuqhubeka nokukhangela le ndawo, uyavumelana nokusebenzisa kwethu iikuki.Iinkcukacha ezithe xaxe.
Ngokucofa “Vumela Konke”, uyavumelana nokugcinwa kweekuki kwisixhobo sakho ukuze kuphuculwe ukukhangelwa kwendawo, ukuhlalutya usetyenziso lwesayithi, kunye nokuxhasa ubonelelo lwethu lokufikelela simahla komxholo wesayensi.Iinkcukacha ezithe xaxe.
Kuphononongo lwakutsha nje olupapashwe kwijenali ye-Pharmaceutics, abaphandi bagqibe ukusebenza kwe-antimicrobial ye-herbal formula ebizwa ngokuba yi-FRO ngokuchasene ne-acne pathogenesis.
Uvavanyo lwe-antimicrobial kunye nohlalutyo lwe-in vitro lubonise ukuba i-FRO ineempembelelo ezibalulekileyo ze-antibacterial kunye ne-anti-inflammatory ngokuchasene ne-Dermatobacillus Acnes (CA), ibhaktheriya ebangela i-acne.Ezi ziphumo zibonisa ukusetyenziswa kwayo okukhuselekileyo kunye nendalo kunyango lwe-cosmetic ye-acne, ukuxhasa ukusetyenziswa kweendlela ezingenayo inetyhefu kunye neendleko ezisebenzayo kumayeza akhoyo ngoku.
Uphononongo: Ukusebenza kwe-FRO kwi-pathogenesis ye-acne vulgaris.Umfanekiso wekhredithi: Steve Jungs/Shutterstock.com
I-Acne vulgaris, eyaziwa ngokuba ngamaqhakuva, yimeko yolusu eqhelekileyo ebangelwa ziifollicle zeenwele ezivalekileyo ezinesebum kunye neeseli zolusu ezifileyo.Iacne ichaphazela ngaphezu kwama-80 ekhulwini olutsha yaye, nangona ingabulali, inokubangela uxinezeleko lwengqondo yaye, kwiimeko ezimandundu, ulusu lube nebala elimibalabala kunye namanxeba.
I-acne iphuma kwintsebenziswano yemfuza kunye nemiba yokusingqongileyo, ehlala ibangelwa utshintsho lwehomoni ehamba kunye nokufikisa ngexesha lokufikisa.Oku kungalingani kwehomoni kwandisa ukuveliswa kwe-sebum kunye nokwandisa i-insulin factor factor 1 (IGF-1) kunye nomsebenzi we-dihydrotestosterone (DHT).
Ukunyuka kwe-sebum secretion kuthathwa njengenqanaba lokuqala ekuphuhliseni i-acne, kuba iifollicle zeenwele ezizaliswe nge-sebum ziqulethe inani elikhulu le-microorganisms ezifana ne-SA.I-SA yinto yendalo ye-commensal yolusu;nangona kunjalo, ukwanda kokwanda kwe-phylotype IA1 kubangela ukuvuvukala kunye ne-pigmentation yeenwele zeenwele kunye neepapules ezibonakalayo ngaphandle.
Kukho iindlela ezahlukeneyo zonyango lwezithambiso ze-acne, ezifana ne-retinoids kunye ne-topical agents ze-microbial, ezisetyenziswa ngokudityaniswa ne-chemical peels, i-laser / light therapy, kunye ne-hormonal agents.Nangona kunjalo, olu nyango luxabisa kakhulu kwaye lunxulunyaniswa neziphumo ebezingalindelekanga ezibi.
Uphononongo lwangaphambili luphonononge izicatshulwa zamachiza njengenye indlela eneendleko zendalo kolu nyango.Njengenye indlela, izicatshulwa zeRhus vulgaris (RV) ziye zaphononongwa.Nangona kunjalo, ukusetyenziswa kwayo kunqunyelwe yi-urushiol, inxalenye ephambili ye-allergenic yalo mthi.
I-FRO i-herbal formula equlethe izicatshulwa ezivundisiweyo ze-RV (FRV) kunye ne-Japan mangosteen (OJ) kumlinganiselo we-1: 1.Ukusebenza kwefomula kuye kwavavanywa kusetyenziswa i-in vitro assays kunye ne-antimicrobial properties.
Umxube we-FRO waqala ukubonakaliswa kusetyenziswa ulwelo oluphezulu lwechromatography (HPLC) ukwahlula, ukuchonga kunye nokulinganisa amacandelo awo.Umxube wahlaziywa ngakumbi kumxholo we-phenolic (TPC) ukuchonga iikhompawundi ezinokuthi zibe neempawu ze-antimicrobial.
Uvavanyo lokuqala lwe-in vitro antimicrobial assay ngokuvavanya uvakalelo lwe-diffusion.Okokuqala, i-CA (phylotype IA1) yayikhuliswe ngokufanayo kwi-agar plate apho i-10 mm ububanzi be-FRO-impregnated filter paper disk yafakwa.Umsebenzi we-Antimicrobial wavavanywa ngokulinganisa ubungakanani bommandla wokuthintela.
Ukusebenza kwe-FRO kwimveliso ye-sebum eyenziwe yi-CA kunye ne-DHT-ehambelana ne-androgen surges yavavanywa kusetyenziswa i-Oil Red staining kunye nohlalutyo lwe-blot yaseNtshona, ngokulandelanayo.I-FRO emva koko yavavanywa amandla ayo okunciphisa imiphumo yeentlobo ze-oksijeni esebenzayo (ROS), ezijongene ne-acne-associated hyperpigmentation kunye nezibazi zasemva kokuhlinzwa, usebenzisa i-2',7'-dichlorofluorescein diacetate (DCF-DA) probe.unobangela.
Iziphumo zovavanyo lokusasazwa kwedisk zibonise ukuba i-20 μL ye-FRO ithintele ngempumelelo ukukhula kwe-CA kwaye yavelisa indawo ebonakalayo yokuthintela ye-13 mm kuxinzelelo lwe-100 mg/mL.I-FRO icinezela kakhulu ukwanda kwe-sebum secretion ebangelwa yi-SA, ngaloo ndlela icothisa okanye ibuyisela umva ukwenzeka kwe-acne.
I-FRO ifunyenwe isityebi kwiikhompawundi ze-phenolic ezibandakanya i-gallic acid, i- kaempferol, i-quercetin kunye ne-fisetin.Iyonke i-phenolic compound (TPC) i-concentration ye-avareji ye-118.2 mg gallic acid equivalents (GAE) ngegram ye-FRO.
I-FRO yanciphisa kakhulu ukuvuvukala kwamaselula okubangelwa yi-ROS eyenziwe yi-SA kunye nokukhululwa kwe-cytokine.Ukunciphisa ixesha elide kwimveliso ye-ROS kunokunciphisa i-hyperpigmentation kunye ne-scarring.
Nangona unyango lwe-dermatological lwe-acne lukhona, luhlala lubiza kwaye lunokuba nemiphumo emibi engafunekiyo.
Iziphumo zibonisa ukuba i-FRO ineempawu zokulwa ne-antibacterial ezichasene ne-CA (i-acne-causing bacteria), ngaloo ndlela ibonisa ukuba i-FRO yinto yendalo, engeyona ityhefu kunye neendleko ezisebenzayo kunyango lwe-acne yendabuko.I-FRO ikwanciphisa imveliso ye-sebum kunye nokubonakaliswa kwehomoni kwi-vitro, ebonisa ukusebenza kwayo ekunyangeni nasekuthinteleni amaqhakuva.
Ulingo lwangaphambili lwezonyango lwe-FRO lubonise ukuba abantu abasebenzisa i-FRO's toner kunye nelotion ephucukileyo baye bafumana uphuculo olubonakalayo kukuqina kwesikhumba kunye namanqanaba okufuma xa kuthelekiswa neqela lolawulo emva kweeveki nje ezintandathu.Nangona olu phononongo aluzange luvavanye i-acne phantsi kweemeko ezilawulwayo ze-vitro, iziphumo zangoku zixhasa iziphumo zabo.
Zithathiwe kunye, ezi ziphumo zixhasa ukusetyenziswa kwexesha elizayo kwe-FRO kunyango lokuthambisa, kubandakanya unyango lwamaqhakuva kunye nokuphucula impilo yolusu iyonke.
Eli nqaku lahlelwa nge-9 kaJuni ngo-2023 ukuze lithathe indawo yomfanekiso ophambili ngowona ufanelekileyo.
Ithunyelwe kwi: Iindaba zeNzululwazi yezoNyango |Iindaba zoPhando lwezoNyango |Iindaba zezifo |Iindaba zamachiza
Tags: amaqhakuva, abafikisayo, androgens, anti-ukudumba, iiseli, chromatography, cytokines, dihydrotestosterone, ukusebenza, ukuvubela, genetics, ukukhula izinto, iinwele, hormone, hyperpigmentation, in vitro, ukudumba, insulin, phototherapy, chromatography elulwelo, ioksijini, ukwanda , i-quercetin, i-retinoids, ulusu, iiseli zolusu, i-pigmentation yesikhumba, i-Western blot
U-Hugo Francisco de Souza ngumbhali wesayensi ose-Bangalore, Karnataka, eIndiya.Izinto anomdla kuzo kwizifundo zebhayoloji, i-evolutionary biology kunye neherpetology.Kungoku nje usebenzela dissertation yakhe yobugqirha.kwiZiko leeNzululwazi zokusiNgqongileyo kwiZiko leSayensi laseIndiya, apho afundela khona imvelaphi, ukusasazwa kunye nenkcazo yeenyoka zomhlaba omanzi.U-Hugo wawongwa nge-DST-INSPIRE Fellowship ngophando lwakhe lobugqirha kunye neMbasa yeGolide kwiYunivesithi yasePondicherry ngenxa yempumelelo yakhe kwizifundo ngexesha lezifundo zakhe ze-Master.Uphando lwakhe luye lwapapashwa kwiijenali eziphononongwe ngoontanga-ziphezulu ezibandakanya i-PLOS engahoywanga yeZifo zeTropiki kunye neBiology yeeNkqubo.Xa engasebenzi kwaye ebhala, u-Hugo uzinkcinkca ngeetoni ze-anime kunye namahlaya, ubhala kwaye aqambe umculo kwi-bass guitar, akrazule iingoma kwi-MTB, adlale imidlalo yevidiyo (ukhetha igama elithi "umdlalo"), okanye i-tinkers nayo nantoni na. .ubugcisa.
UFrancisco de Souza, uHugo.(NgoJulayi 9, 2023).Umxube oyingqayizivele wezityalo zezityalo ubonelela ngeenzuzo ezinamandla zokulwa ne-acne.Iindaba - Zonyango.Ifunyenwe ngoSeptemba 11, 2023, ukusuka ku-https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
UFrancisco de Souza, uHugo."Umxube okhethekileyo wezityalo ezineepropathi ezinamandla zokulwa ne-acne."Iindaba - Zonyango.NgoSeptemba 11, 2023.
UFrancisco de Souza, uHugo."Umxube okhethekileyo wezityalo ezineepropathi ezinamandla zokulwa ne-acne."Iindaba - Zonyango.https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.(Ifikelelwe ngoSeptemba 11, 2023).
UFrancisco de Souza, uHugo.2023. Umxube oyingqayizivele wezityalo zezityalo ezineempawu ezinamandla zokulwa ne-acne.Iindaba zoNyango, zifike ngoSeptemba 11, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Iifoto ezisetyenziswe kwesi "sishwankathelo" azihambelani nesi sifundo kwaye zilahlekisa ngokupheleleyo ekucebiseni ukuba uphando lubandakanya uvavanyo ebantwini.Kufuneka isuswe ngokukhawuleza.
Kudliwano-ndlebe olwenziwa kwinkomfa ye-SLAS EU 2023 eBrussels, eBelgium, sathetha noSilvio Di Castro malunga nophando lwakhe kunye nendima yokulawula i-compound kuphando lwamachiza.
Kule podcast entsha, uKeith Stumpo kaBruker uxoxa ngamathuba amaninzi eemveliso zendalo kunye noPelle Simpson ka-Enveda.
Kulo dliwano-ndlebe, i-NewsMedical ithetha ne-Quantum-Si CEO uJeff Hawkins malunga nemingeni yeendlela zendabuko kwiiproteomics kunye nendlela isizukulwana esilandelayo sokulandelelana kweeprotheyini sinokwenza idemokhrasi ukulandelelana kweprotheyini.
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