Sisebenzisa iikuki ukuphucula amava akho. Ngokuqhubeka ukhangela le sayithi, uyavuma ukuba sisebenzise iikuki. Ulwazi oluthe kratya.
Ngokucofa u-"Vumela Konke", uyavuma ukuba iikuki zigcinwe kwisixhobo sakho ukuphucula ukuzulazula kwesiza, ukuhlalutya ukusetyenziswa kwesiza, kunye nokuxhasa ukubonelelwa kwethu komxholo wesayensi ovulelekileyo nowasimahla. Ulwazi oluthe kratya.
Kuphononongo lwakutshanje olupapashwe kwiphephancwadi i-Pharmaceutics, abaphandi bafumanise ukusebenza kakuhle kwefomyula yezityalo ebizwa ngokuba yi-FRO ukulwa nesifo se-acne.
Uvavanyo lwe-antimicrobial kunye nohlalutyo lwe-in vitro lubonise ukuba i-FRO inemiphumo ebalulekileyo yokulwa neentsholongwane kunye nokudumba kwi-Dermatobacillus Acnes (CA), intsholongwane ebangela i-acne. Ezi ziphumo zibonisa ukusetyenziswa kwayo okukhuselekileyo nokwendalo kunyango lwe-acne, zixhasa ukusetyenziswa kwezinye iindlela ezingenabungozi nezingabizi kakhulu kunezonyango zangoku ze-acne.
Uphononongo: Ukusebenza kakuhle kwe-FRO kwi-pathogenesis ye-acne vulgaris. Umfanekiso: Steve Jungs/Shutterstock.com
I-Acne vulgaris, eyaziwa ngokuba zii-pimples, yimeko eqhelekileyo yesikhumba ebangelwa zii-follicles zeenwele ezivalekileyo ezine-sebum kunye neeseli zesikhumba ezifileyo. I-Acne ichaphazela ngaphezulu kwama-80 ekhulwini abantu abaselula kwaye, nangona ingabulali, inokubangela uxinzelelo lwengqondo kwaye, kwiimeko ezinzima, inokubangela ukuba umbala wesikhumba ungapheli kunye namanxeba.
I-acne ibangelwa kukudibana kwezinto zemfuza kunye neemeko ezingqongileyo, ezidla ngokubangelwa lutshintsho lweehomoni oluhamba nokufikisa ngexesha lokufikisa. Oku kungalingani kweehomoni kwandisa imveliso ye-sebum kwaye kwandisa umsebenzi we-insulin growth factor 1 (IGF-1) kunye nomsebenzi we-dihydrotestosterone (DHT).
Ukwanda kokukhutshwa kwe-sebum kuthathwa njengenqanaba lokuqala ekuphuhlisweni kwe-acne, kuba ii-follicles zeenwele ezigcwele i-sebum ziqulathe inani elikhulu lee-microorganisms ezifana ne-SA. I-SA yinto yendalo eyenzeka eluswini; nangona kunjalo, ukwanda kohlobo lwayo lwe-phylotype IA1 kubangela ukudumba kunye nokuguquka kwemibala yee-follicles zeenwele ngee-papules ezibonakalayo ngaphandle.
Kukho iindlela ezahlukeneyo zonyango lobuhle kwi-acne, ezifana nee-retinoids kunye nee-microbial agents ezisetyenziswa xa zidityaniswe namaxolo eekhemikhali, unyango lwe-laser/light, kunye nee-hormone agents. Nangona kunjalo, olu nyango lubiza kakhulu kwaye lunxulunyaniswa nemiphumo emibi.
Izifundo zangaphambili zihlolisise izicatshulwa zezityalo njengendlela yendalo engabizi kakhulu kunezi zonyango. Njengenye indlela, izicatshulwa zeRhus vulgaris (RV) ziye zafundwa. Nangona kunjalo, ukusetyenziswa kwayo kunqunyelwe yi-urushiol, into ephambili ebangela ukuba umthi ungabi namdla.
I-FRO yifomyula yemifuno equlethe izicatshulwa ze-RV (FRV) kunye ne-Japanese mangosteen (OJ) ezivundisiweyo kumlinganiselo we-1:1. Ukusebenza kakuhle kwale fomyula kuhlolwe kusetyenziswa iimvavanyo ze-in vitro kunye neempawu zokulwa neentsholongwane.
Umxube we-FRO waqala wachazwa kusetyenziswa i-high performance liquid chromatography (HPLC) ukuze kwahlulwe, kuchongwe kwaye kulinganiswe izinto ezikuwo. Umxube wahlalutywa ngakumbi ukuze kufunyanwe umxholo we-phenolic opheleleyo (TPC) ukuze kufunyanwe iikhompawundi ezinokuba neempawu zokulwa ne-antimicrobial.
Uvavanyo lokuqala lwe-in vitro antimicrobial ngokuvavanya uvakalelo lokusasazwa kwediski. Okokuqala, i-CA (phylotype IA1) yatyalwa ngokulinganayo kwipleyiti ye-agar apho kwabekwa khona idiski yephepha lesihluzo elifakwe i-FRO enobubanzi obuyi-10 mm. Umsebenzi we-antimicrobial wavavanywa ngokulinganisa ubungakanani bendawo yokuthintela.
Ukusebenza kwe-FRO kwimveliso ye-sebum ebangelwa yi-CA kunye nokunyuka kwe-androgen enxulumene ne-DHT kuhlolwe kusetyenziswa i-Oil Red staining kunye nohlalutyo lwe-Western blot, ngokwahlukeneyo. I-FRO emva koko yavavanywa ukukwazi kwayo ukuphelisa iziphumo ze-reactive oxygen species (ROS), ezibangela i-acne-associated hyperpigmentation kunye namabala emva kotyando, kusetyenziswa i-2′,7′-dichlorofluorescein diacetate (DCF-DA) probe.
Iziphumo zovavanyo lokusasazwa kwediski zibonise ukuba i-20 μL ye-FRO ithintele ngempumelelo ukukhula kwe-CA kwaye ivelise indawo ecacileyo yokuthintela ye-13 mm kuxinzelelo lwe-100 mg/mL. I-FRO ithintela kakhulu ukwanda kokukhutshwa kwe-sebum okubangelwa yi-SA, ngaloo ndlela inciphisa okanye ibuyisele umva ukwenzeka kwe-acne.
Kufunyenwe ukuba i-FRO ityebile kwiikhompawundi ze-phenolic eziquka i-gallic acid, i-kaempferol, i-quercetin kunye ne-fisetin. Uxinzelelo lwe-phenolic compound (TPC) iyonke luyi-118.2 mg ye-gallic acid equivalents (GAE) ngegram nganye ye-FRO.
I-FRO inciphise kakhulu ukudumba kweeseli okubangelwa yi-SA-induced ROS kunye nokukhululwa kwe-cytokine. Ukunciphisa imveliso ye-ROS ixesha elide kunokunciphisa i-hyperpigmentation kunye namanxeba.
Nangona kukho unyango lwesikhumba olusebenzisa i-acne, ludla ngokubiza kakhulu kwaye lunokuba nemiphumo emibi emininzi engafunekiyo.
Iziphumo zibonisa ukuba i-FRO ineempawu zokulwa ne-antibacterial ngokuchasene ne-CA (iintsholongwane ezibangela i-acne), ngaloo ndlela zibonisa ukuba i-FRO yindlela yendalo, engenabungozi kwaye engabizi kakhulu kunonyango lwendabuko lwe-acne. I-FRO ikwanciphisa ukuveliswa kwe-sebum kunye nokubonakaliswa kwehomoni kwi-vitro, ibonisa ukusebenza kwayo ekunyangeni nasekuthinteleni ukuqhambuka kwe-acne.
Uvavanyo lweklinikhi lwangaphambili lwe-FRO lubonise ukuba abantu abasebenzisa i-toner kunye ne-lotion ephucukileyo ye-FRO baye bafumana uphuculo olukhulu kumanqanaba okuqina kolusu kunye nokufuma xa kuthelekiswa neqela lolawulo emva kweeveki ezintandathu kuphela. Nangona olu phononongo lungakhange luvavanye i-acne phantsi kweemeko ezilawulwayo kwi-vitro, iziphumo zangoku zixhasa iziphumo zabo.
Xa zizonke, ezi ziphumo zixhasa ukusetyenziswa kwe-FRO kwixesha elizayo kunyango lobuhle, kubandakanya unyango lwe-acne kunye nokuphucula impilo yolusu iyonke.
Eli nqaku lihlelwe nge-9 kaJuni 2023 ukuze kufakwe umfanekiso ophambili endaweni yawo.
Iposiwe kwi: Iindaba zeSayensi yezonyango | Iindaba zoPhando lwezonyango | Iindaba zeSifo | Iindaba zamayeza
Iithegi: i-acne, ulutsha, ii-androgens, i-anti-inflammatory, iiseli, i-chromatography, ii-cytokines, i-dihydrotestosterone, ukusebenza kakuhle, ukubila, i-genetics, izinto zokukhula, iinwele, iihomoni, i-hyperpigmentation, i-in vitro, ukudumba, i-insulin, i-phototherapy, i-chromatography yolwelo, ioksijini, ukwanda, i-quercetin, ii-retinoids, ulusu, iiseli zesikhumba, i-pigmentation yolusu, i-Western blot
UHugo Francisco de Souza ngumbhali wesayensi ohlala eBangalore, eKarnataka, eIndiya. Izinto anomdla kuzo kwezemfundo zikwimiba ye-biogeography, i-evolutionary biology kunye ne-herpetology. Okwangoku usebenza kwi-dissertation yakhe yobugqirha, evela kwiZiko leSayensi yeNdalo kwi-Indian Institute of Science, apho afunda khona imvelaphi, ukusasazwa kunye nokuchazwa kweenyoka zasemanzini. UHugo wanikwa i-DST-INSPIRE Fellowship ngophando lwakhe lobugqirha kunye neMbasa yeGolide kwiYunivesithi yasePondicherry ngenxa yempumelelo yakhe yezemfundo ngexesha lezifundo zakhe zeMasters. Uphando lwakhe lupapashwe kwiijenali eziphononongwa ngontanga eziquka i-PLOS Neglected Tropical Diseases kunye ne-Systems Biology. Xa engasebenzi kwaye ebhala, uHugo usebenzisa i-anime eninzi kunye nee-comics, ubhala kwaye aqambe umculo kwi-bass guitar, uqhekeza iingoma kwi-MTB, udlala imidlalo yevidiyo (ukhetha igama elithi "umdlalo"), okanye atshintshe phantse nantoni na. ubuchwepheshe.
UFrancisco de Souza, eHugo. (Julayi 9, 2023). Umxube owahlukileyo wezicatshulwa zezityalo unika iingenelo ezinamandla zokulwa namaqhakuva. Iindaba – Ezonyango. Ifunyenwe nge-11 kaSeptemba, 2023, kwi-https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
UFrancisco de Souza, uHugo. “Umxube owahlukileyo wezicatshulwa zezityalo ezineempawu ezinamandla zokulwa namaqhakuva.” Iindaba – Ezonyango. Septemba 11, 2023.
UFrancisco de Souza, uHugo. “Umxube okhethekileyo wezityalo ezithathwe kwizityalo ezineempawu ezinamandla zokulwa namaqhakuva.” Iindaba – Ezonyango. https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx. (Kufikelelwe ngoSeptemba 11, 2023).
UFrancisco de Souza, eHugo. 2023. Umxube owahlukileyo wezityalo ezithathwe kwizityalo ezineempawu ezinamandla zokulwa namaqhakuva. Iindaba zezonyango, zifikelelwe nge-11 kaSeptemba, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Iifoto ezisetyenzisiweyo kolu "shwankathelo" azinxulumananga nolu phando kwaye ziyakhohlisa ngokupheleleyo xa zisithi olu phando lubandakanya uvavanyo ebantwini. Kufuneka lususwe ngoko nangoko.
Kudliwanondlebe olwenziwe kwingqungquthela ye-SLAS EU 2023 eBrussels, eBelgium, sithethe noSilvio Di Castro malunga nophando lwakhe kunye nendima yolawulo lwe-compound kuphando lwezemithi.
Kule podcast intsha, uKeith Stumpo waseBruker uxoxa ngamathuba eemveliso zendalo ezininzi kunye noPelle Simpson wase-Enveda.
Kolu dliwanondlebe, iNewsMedical ithetha ne-CEO yeQuantum-Si uJeff Hawkins malunga nemingeni yeendlela zemveli zokusebenzisa i-proteomics kunye nendlela ukulandelelana kweeproteni zesizukulwana esilandelayo okunokunciphisa ngayo ukulandelelana kweeproteni.
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