I-Berberine, okanye i-berberine hydrochloride, yikhompawundi efumaneka kwizityalo ezininzi. Inokunceda ekunyangeni izifo ezifana nesifo seswekile, i-cholesterol ephezulu kunye noxinzelelo lwegazi oluphezulu. Nangona kunjalo, iziphumo ebezingalindelekanga zingabandakanya ukudumba kwesisu kunye nokucaphuka.
IBerberine ibiyinxalenye yezonyango zemveli zaseTshayina nase-Ayurvedic kangangeminyaka engamawaka. Isebenza emzimbeni ngeendlela ezahlukeneyo kwaye inokubangela utshintsho kwiiseli zomzimba.
Uphando olwenziwe kwi-berberine lubonisa ukuba inokunyangela izifo ezahlukeneyo ze-metabolic, kuquka isifo seswekile, ukutyeba kakhulu, kunye nesifo sentliziyo. Ingaphucula nempilo yamathumbu.
Nangona i-berberine ibonakala ikhuselekile kwaye inemiphumo emibi embalwa, kufuneka udibane nogqirha wakho ngaphambi kokuba uyithathe.
I-Berberine isenokuba sisixhobo esisebenzayo sokulwa neentsholongwane. Uphononongo luka-2022 lufumanise ukuba i-berberine inceda ekuthinteleni ukukhula kwe-Staphylococcus aureus.
Olunye uphando lufumanise ukuba i-berberine inokonakalisa i-DNA kunye neeproteni zebhaktheriya ezithile.
Uphando lubonisa ukuba i-berberine ineempawu zokulwa nokuvuvukala, oko kuthetha ukuba inokunceda ekunyangeni isifo seswekile kunye nezinye izifo ezinxulumene nokuvuvukala.
Uphando lubonisa ukuba i-berberine inokuba luncedo ekunyangeni isifo seswekile. Uphando lubonise ukuba inokuba nefuthe elihle kwi:
Uhlalutyo olufanayo lufumanise ukuba indibaniselwano yeberberine kunye neyeza elinciphisa iswekile egazini yayisebenza ngcono kunezo zombini ezi ziyobisi zodwa.
Ngokwesifundo sika-2014, i-berberine ithembisa njengonyango olunokwenzeka lwesifo seswekile, ingakumbi kubantu abangenakuthatha amayeza okulwa nesifo seswekile ngenxa yesifo sentliziyo, ukungasebenzi kakuhle kwesibindi, okanye iingxaki zezintso.
Olunye uphononongo lweencwadi lufumanise ukuba i-berberine kunye notshintsho kwindlela yokuphila kunciphisa amanqanaba eswekile yegazi ngaphezu kotshintsho kwindlela yokuphila yodwa.
Kubonakala ngathi iBerberine ivuselela i-AMP-activated protein kinase, enceda ekulawuleni ukusetyenziswa kweswekile egazini ngumzimba. Abaphandi bakholelwa ukuba oku kusebenza kunokunceda ekunyangeni isifo seswekile kunye neengxaki zempilo ezinxulumene noko ezifana nokutyeba kakhulu kunye ne-cholesterol ephezulu.
Olunye uhlalutyo lwe-meta-analysis luka-2020 lubonise ukuphucuka kobunzima bomzimba kunye neeparameter ze-metabolic ngaphandle kokunyuka okukhulu komsebenzi we-enzyme yesibindi.
Nangona kunjalo, izazinzulu kufuneka zenze izifundo ezinkulu nezingaboniyo ukuze ziqinisekise ngokupheleleyo ukhuseleko kunye nokusebenza kakuhle kweberberine.
Thetha nogqirha wakho ngaphambi kokuba usebenzise i-berberine yesifo seswekile. Isenokungafaneleki kuye wonke umntu kwaye isenokudibana namanye amayeza.
Amanqanaba aphezulu e-cholesterol kunye ne-low-density lipoprotein (LDL) triglycerides anokunyusa umngcipheko wesifo sentliziyo kunye nesifo sohlangothi.
Ubungqina obuthile bubonisa ukuba i-berberine inokunceda ukwehlisa i-cholesterol ye-LDL kunye ne-triglycerides. Ngokutsho kolunye uphononongo, izifundo zezilwanyana kunye nabantu zibonisa ukuba i-berberine iyayinciphisa i-cholesterol.
Oku kunokunceda ukwehlisa i-LDL, i-cholesterol "embi", kwaye kwandiswe i-HDL, i-cholesterol "elungileyo".
Uphononongo lweencwadi lufumanise ukuba i-berberine kunye notshintsho kwindlela yokuphila kusebenza ngakumbi ekunyangeni i-cholesterol ephezulu kunotshintsho kwindlela yokuphila yodwa.
Abaphandi bakholelwa ukuba i-berberine inokusebenza ngendlela efanayo namayeza okunciphisa i-cholesterol ngaphandle kokubangela iziphumo ebezingalindelekanga ezifanayo.
Uphononongo lweencwadi lufumanise ukuba i-berberine yayisebenza ngakumbi xa idityaniswe namayeza okunciphisa uxinzelelo lwegazi kunokuba ingasebenzi yodwa.
Ukongeza, iziphumo ezivela kwizifundo zeempuku zibonisa ukuba i-berberine inokulibazisa ukuqala koxinzelelo lwegazi oluphezulu kwaye incede ekunciphiseni ubukhali bayo xa uxinzelelo lwegazi oluphezulu luvela.
Olunye uphononongo lubike ukwehla okukhulu kobunzima kubantu abathatha i-750 milligrams (mg) ye-barberry kabini ngemini kangangeenyanga ezi-3. I-Barberry sisityalo esine-berberine eninzi.
Ukongeza, uphando olungaboniyo lufumanise ukuba abantu abane-metabolic syndrome abathatha i-200 mg ye-barberry kathathu ngemini babene-body mass index ephantsi.
Iqela elenza olunye uphando liphawule ukuba i-berberine inokwenza izicubu ze-adipose ezimdaka zisebenze. Ezi zicubu zinceda umzimba ukuguqula ukutya kube bubushushu bomzimba, kwaye ukusebenza okwandisiweyo kunokunceda ekunyangeni ukutyeba kakhulu kunye nesifo se-metabolic syndrome.
Ezinye izifundo zibonisa ukuba i-berberine isebenza ngendlela efanayo neyeza le-metformin, elidla ngokunikwa ngoogqirha ukunyanga isifo seswekile sohlobo lwesibini. Enyanisweni, i-berberine inokuba nakho ukutshintsha iintsholongwane zamathumbu, nto leyo enokunceda ekunyangeni ukutyeba kakhulu nesifo seswekile.
I-Polycystic ovary syndrome (PCOS) yenzeka xa abafazi benamanqanaba aphezulu eehomoni ezithile zamadoda. Le syndrome kukungalingani kweehomoni kunye ne-metabolic okunokubangela ukungazali kunye nezinye iingxaki zempilo.
I-Polycystic ovary syndrome inxulunyaniswa neengxaki ezininzi ezinokunceda ekusombululeni i-berberine. Umzekelo, abantu abane-PCOS banokuba nazo:
Ngamanye amaxesha oogqirha banika i-metformin, iyeza lesifo seswekile, ukunyanga i-PCOS. Ekubeni i-berberine inemiphumo efanayo ne-metformin, isenokuba lolona khetho lulungileyo lonyango lwe-PCOS.
Uphononongo olucwangcisiweyo lufumanise ukuba i-berberine ithembisayo kunyango lwe-polycystic ovary syndrome kunye nokuxhathisa i-insulin. Nangona kunjalo, ababhali baqaphela ukuba ukuqinisekiswa kwezi ziphumo kufuna uphando olongezelelekileyo.
I-Berberine inokubangela utshintsho kwiimolekyuli zeseli, ezinokuba nenye inzuzo enokubakho: ukulwa nomhlaza.
Olunye uphando lubonisa ukuba i-berberine inceda ekunyangeni umhlaza ngokuthintela inkqubela yawo kunye nomjikelo wobomi oqhelekileyo. Ingadlala indima ekubulaleni iiseli zomhlaza.
Ngokusekelwe kolu lwazi, ababhali bathi i-berberine liyeza "elisebenzayo kakhulu, elikhuselekileyo, nelifikelelekayo" lokulwa nomhlaza.
Nangona kunjalo, kubalulekile ukukhumbula ukuba abaphandi bafunde kuphela imiphumo ye-berberine kwiiseli zomhlaza kwilebhu kwaye kungekhona ebantwini.
Ngokwezinye izifundo ezapapashwa ngo-2020, ukuba i-berberine inokunceda ekunyangeni umhlaza, ukudumba, isifo seswekile kunye nezinye izifo, kusenokwenzeka ukuba kungenxa yemiphumo yayo emihle kwi-gut microbiome. Izazinzulu zifumene unxibelelwano phakathi kwe-gut microbiome (iikholoni zeebhaktheriya emathunjini) kunye nezi meko.
I-Berberine ineempawu zokulwa neentsholongwane kwaye isusa iintsholongwane eziyingozi emathunjini, ngaloo ndlela ikhuthaza ukukhula kweentsholongwane ezisempilweni.
Nangona izifundo ebantwini nakwiimpuku zibonisa ukuba oku kusenokuba yinyani, izazinzulu zilumkisa ukuba kufuneka uphando olongezelelekileyo ukuqinisekisa indlela i-berberine ebachaphazela ngayo abantu kunye nokuba ikhuselekile na ukuyisebenzisa.
I-American Association of Naturopathic Physicians (AANP) ithi izongezo zeberberine ziyafumaneka kwifom yesongezelelo okanye kwifomu yecapsule.
Bathi izifundo ezininzi zicebisa ukuba kuthathwe i-900-1500 mg ngosuku, kodwa uninzi lwabantu luthatha i-500 mg kathathu ngemini. Nangona kunjalo, i-AANP ikhuthaza abantu ukuba babonane nogqirha ngaphambi kokuba bathathe i-berberine ukuze bajonge ukuba ikhuselekile na ukuyisebenzisa kwaye ingasetyenziswa ngaluphi na umlinganiselo.
Ukuba ugqirha uyavuma ukuba i-berberine ikhuselekile ukuyisebenzisa, abantu kufuneka bajonge ilebhile yemveliso ukuze babone ukuba iqinisekisiwe na, njengeNational Science Foundation (NSF) okanye i-NSF International, itsho njalo i-AANP.
Ababhali bophando olwenziwe ngo-2018 bafumanise ukuba umxholo wee-capsules ze-berberine ezahlukeneyo wahluka kakhulu, nto leyo enokubangela ukudideka malunga nokhuseleko kunye nomthamo. Abazange bafumanise ukuba iindleko eziphezulu zibonisa umgangatho ophezulu wemveliso.
I-US Food and Drug Administration (FDA) ayilawuli izongezo zokutya. Akukho siqinisekiso sokuba izongezo zikhuselekile okanye ziyasebenza, kwaye akunakwenzeka rhoqo ukuqinisekisa umgangatho wemveliso.
Izazinzulu zithi i-berberine kunye ne-metformin zabelana ngeempawu ezininzi kwaye zombini zinokuba luncedo ekunyangeni isifo seswekile sohlobo lwesibini.
Nangona kunjalo, ukuba ugqirha unika umntu i-metformin, akufanele acinge nge-berberine njengenye indlela ngaphandle kokuxoxa ngayo nogqirha wakhe kuqala.
Oogqirha baya kunika umntu idosi echanekileyo ye-metformin ngokusekelwe kwizifundo zeklinikhi. Akunakwenzeka ukwazi ukuba izongezo zihambelana njani nale mali.
I-Berberine inokusebenzisana ne-metformin kwaye ichaphazele iswekile yakho yegazi, nto leyo eyenza kube nzima ukuyilawula. Kolunye uphando, ukuthatha i-berberine kunye ne-metformin kunye kunciphisa imiphumo ye-metformin ngama-25%.
I-Berberine isenokuba yindlela efanelekileyo yokulawula iswekile egazini endaweni ye-metformin, kodwa uphando oluthe kratya luyafuneka.
IZiko leSizwe lezeMpilo eNtlanganisela neHlanganisayo (i-NCCIH) lithi i-goldenrod, equlethe i-berberine, ayinakubangela iziphumo ebezingalindelekanga kwixesha elifutshane ukuba abantu abadala bayithatha ngomlomo. Nangona kunjalo, akukho lwazi lwaneleyo lokubonisa ukuba ikhuselekile ukusetyenziswa ixesha elide.
Kwizifundo zezilwanyana, izazinzulu ziqaphele ezi ziphumo zilandelayo ngokuxhomekeke kuhlobo lwesilwanyana, ubungakanani kunye nobude bokusetyenziswa kwaso:
Kubalulekile ukuthetha nogqirha wakho ngaphambi kokuba uthathe i-berberine okanye ezinye izongezo kuba zisenokungakhuseleki kwaye zisenokungafaneleki kuye wonke umntu. Nabani na onesifo sokunganyamezelani naso nasiphi na isithako semifuno kufuneka ayeke ukuyisebenzisa ngoko nangoko.