I-Berberine, okanye i-berberine hydrochloride, yikhompawundi efumaneka kwizityalo ezininzi. Inokunceda ukunyanga iimeko ezifana nesifo seswekile, i-cholesterol ephezulu kunye noxinzelelo lwegazi oluphezulu. Nangona kunjalo, iziphumo ebezingalindelekanga zinokubandakanya isisu kunye nesicaphucaphu.
IBerberine ibiyinxalenye yeyeza lemveli laseTshayina kunye ne-Ayurvedic kangangamawaka eminyaka. Isebenza emzimbeni ngeendlela ezahlukeneyo kwaye iyakwazi ukwenza utshintsho kwiiseli zomzimba.
Uphando nge-berberine lucebisa ukuba inokunyanga izifo ezahlukeneyo ze-metabolic, kubandakanya isifo seswekile, ukutyeba, kunye nesifo sentliziyo. Isenokuphucula impilo yamathumbu.
Nangona i-berberine ibonakala ikhuselekile kwaye ineziphumo ebezingalindelekanga ezimbalwa, kufuneka udibane nogqirha wakho ngaphambi kokuba uyithathe.
I-Berberine inokuba yi-agent esebenzayo ye-antibacterial. Uphononongo luka-2022 lwafumanisa ukuba i-berberine inceda ukuthintela ukukhula kwe-Staphylococcus aureus.
Olunye uphando lwafumanisa ukuba i-berberine inokonakalisa i-DNA kunye neeprotheni zezinye iibhaktheriya.
Uphando lubonisa ukuba i-berberine inezixhobo ezichasayo, oku kuthetha ukuba inokunceda ukunyanga isifo seswekile kunye nezinye izifo ezinxulumene nokudumba.
Uphando lubonisa ukuba i-berberine inokuba luncedo ekunyangeni isifo seswekile. Uphando lubonise ukuba lunokuba nefuthe elihle kwi:
Uhlalutyo olufanayo lufumanise ukuba indibaniselwano ye-berberine kunye nechiza elehlisa iswekile esegazini lalisebenza ngakumbi kunelichiza lodwa.
Ngokutsho kophononongo lwe-2014, i-berberine ibonisa isithembiso njengonyango olunokubakho kwisifo seswekile, ngakumbi kubantu abangakwaziyo ukuthatha iziyobisi ezikhoyo ze-antidiabetic ngenxa yesifo senhliziyo, ukungaphumeleli kwesibindi, okanye iingxaki zezintso.
Olunye uphononongo lweencwadi lufumene ukuba i-berberine idibene nokutshintsha kwendlela yokuphila yanciphisa amanqanaba eswekile yegazi ngaphezu kokutshintsha kwendlela yokuphila yodwa.
I-Berberine ibonakala ivula i-AMP-activated protein kinase, enceda ukulawula ukusetyenziswa komzimba weswekile yegazi. Abaphandi bakholelwa ukuba oku kusebenze kunokunceda ukunyanga isifo seswekile kunye neengxaki zempilo ezinxulumene nokutyeba kunye ne-cholesterol ephezulu.
Olunye uhlalutyo lwe-meta luka-2020 lubonise ukuphucuka kobunzima bomzimba kunye neeparamitha ze-metabolic ngaphandle kokunyuka okubonakalayo kumsebenzi we-enzyme yesibindi.
Nangona kunjalo, izazinzulu kufuneka ziqhube izifundo ezinkulu, ezizimfama kabini ukumisela ngokupheleleyo ukhuseleko kunye nokusebenza kakuhle kweberberine.
Thetha nogqirha wakho ngaphambi kokuba uthathe i-berberine yesifo sikashukela. Isenokungafanelanga wonke umntu kwaye inokunxibelelana namanye amayeza.
Amanqanaba aphezulu e-cholesterol kunye ne-low-density lipoprotein (LDL) triglycerides inokunyusa ingozi yesifo senhliziyo kunye nesifo sohlangothi.
Obunye ubungqina bubonisa ukuba i-berberine inokunceda ukunciphisa i-cholesterol ye-LDL kunye ne-triglycerides. Ngokophononongo olunye, izifundo zezilwanyana kunye nabantu zibonisa ukuba i-berberine yehlisa i-cholesterol.
Oku kunokunceda ukunciphisa i-LDL, i-cholesterol "embi", kwaye yandise i-HDL, i-cholesterol "elungileyo".
Uphononongo loncwadi lufumene ukuba i-berberine idityaniswe nokutshintsha kwendlela yokuphila isebenza ngakumbi ekunyangeni i-cholesterol ephezulu kunokutshintsha indlela yokuphila yodwa.
Abaphandi bakholelwa ukuba i-berberine inokusebenza ngokufanayo kwiziyobisi ezinciphisa i-cholesterol ngaphandle kokubangela iziphumo ezibi ezifanayo.
Uphononongo loncwadi lufumene ukuba i-berberine yayisebenza ngakumbi ngokudibanisa neziyobisi zokunciphisa uxinzelelo lwegazi kunokuba yodwa.
Ukongezelela, iziphumo ezivela kwizifundo zegundane zibonisa ukuba i-berberine inokulibazisa ukuqala koxinzelelo lwegazi kwaye incede ukunciphisa ubunzima bayo xa uxinzelelo lwegazi lwenzeka.
Olunye uphononongo luchaze ukulahleka kwesisindo esibalulekileyo kubantu abathatha i-750 milligrams (mg) ye-barberry kabini imihla ngemihla kwiinyanga ezi-3. IBarberry sisityalo esiqulethe i-berberine eninzi.
Ukongeza, uphononongo oluyimfama kabini lufumanise ukuba abantu abane-metabolic syndrome abathatha i-200 mg ye-barberry kathathu ngemini babenesalathiso esisezantsi sobunzima bomzimba.
Iqela eliqhuba olunye uphononongo liqaphele ukuba i-berberine inokusebenzisa izicubu ze-adipose ezimdaka. Esi sihlunu sinceda umzimba ukuguqula ukutya kube bubushushu bomzimba, kwaye ukwenziwa kusebenze okwandisiweyo kunokunceda ukunyanga ukutyeba kunye nesifo se-metabolic syndrome.
Olunye uphononongo lubonisa ukuba i-berberine isebenza ngokufanayo kwiyeza le-metformin, apho oogqirha bahlala bemisela ukunyanga isifo seswekile se-2. Ngapha koko, i-berberine inokuba namandla okuguqula iibhaktheriya zamathumbu, ezinokunceda ukunyanga ukutyeba kunye nesifo seswekile.
I-Polycystic ovary syndrome (PCOS) yenzeka xa abafazi benezinga eliphezulu leehomoni ezithile zamadoda. I-syndrome kukungalingani kwehomoni kunye nemetabolism enokukhokelela kubudlolo kunye nezinye iingxaki zempilo.
I-Polycystic ovary syndrome inxulumene neengxaki ezininzi ezinokuthi i-berberine incede ukuxazulula. Ngokomzekelo, abantu abane-PCOS banokuba:
Ngamanye amaxesha oogqirha bamisela i-metformin, iyeza lesifo seswekile, ukunyanga i-PCOS. Kuba i-berberine ineziphumo ezifanayo kwi-metformin, inokuba lukhetho olulungileyo lonyango lwe-PCOS.
Uphononongo olucwangcisiweyo lufumene i-berberine ukuba iyathembisa kunyango lwe-polycystic ovary syndrome kunye nokumelana ne-insulin. Nangona kunjalo, ababhali baqaphela ukuba ukuqinisekiswa kwezi ziphumo kufuna uphando olongezelelweyo.
I-Berberine inokubangela utshintsho kwiimolekyuli zeselula, ezinokuthi zibe nenye inzuzo enokubakho: ukulwa nomhlaza.
Olunye uphononongo lucebisa ukuba i-berberine inceda ukunyanga umhlaza ngokuthintela ukuqhubeka kwayo kunye nomjikelo wobomi oqhelekileyo. Isenokudlala indima ekubulaleni iiseli zomhlaza.
Ngokusekwe kwezi datha, ababhali bathi iberberine "lichiza elisebenza kakhulu, likhuselekile, kwaye lifikelelekayo".
Nangona kunjalo, kubalulekile ukukhumbula ukuba abaphandi bafunda kuphela iziphumo zeberberine kwiiseli zomhlaza kwilabhoratri hayi ebantwini.
Ngokwezinye izifundo ezipapashwe ngo-2020, ukuba i-berberine inokunceda ukunyanga umhlaza, ukudumba, isifo seswekile kunye nezinye izifo, inokuba kungenxa yeziphumo zayo eziluncedo kwi-gut microbiome. Iingcali zenzululwazi zifumene ikhonkco phakathi kwe-gut microbiome (iikholoni zebhaktheriya emathunjini) kunye nezi meko.
I-Berberine ineempawu zokulwa ne-antibacterial kwaye isusa iibhaktheriya ezinobungozi emathunjini, ngaloo ndlela ikhuthaza ukukhula kweebhaktheriya eziphilileyo.
Ngelixa uphononongo ebantwini kunye neempuku lucebisa ukuba oku kunokuba yinyani, izazinzulu zilumkisa ukuba uphando oluninzi luyafuneka ukuze kuqinisekiswe ukuba i-berberine ibachaphazela njani abantu nokuba ikhuselekile na ukuyisebenzisa.
I-American Association of Naturopathic Physicians (AANP) ithi i-berberine supplements ifumaneka kwi-supplement okanye ifom ye-capsule.
Bongeza ukuba izifundo ezininzi zincoma ukuthatha i-900-1500 mg ngosuku, kodwa abaninzi abantu bathatha i-500 mg kathathu ngosuku. Nangona kunjalo, i-AANP ibongoza abantu ukuba badibane nogqirha phambi kokuba bathathe i-berberine ukuze bajonge ukuba ikhuselekile na ukuyisebenzisa kwaye ithini idosi enokuthi ithathwe.
Ukuba ugqirha uyavuma ukuba i-berberine ikhuselekile ukuyisebenzisa, abantu kufuneka bahlole ileyibhile yemveliso yesatifikethi somntu wesithathu, njenge-National Science Foundation (NSF) okanye i-NSF International, ithi i-AANP.
Ababhali bophononongo lwe-2018 bafumanisa ukuba umxholo wee-capsules ezahlukeneyo ze-berberine zahluka ngokubanzi, ezinokubangela ukudideka malunga nokhuseleko kunye nedosi. Abakhange bafumanise ukuba iindleko eziphezulu zibonisa umgangatho ophezulu wemveliso.
I-US Food and Drug Administration (FDA) ayilawuli izongezo zokutya. Akukho siqinisekiso sokuba izongezo zikhuselekile okanye ziyasebenza, kwaye akusoloko kunokwenzeka ukuqinisekisa umgangatho wemveliso.
Izazinzulu zithi i-berberine kunye ne-metformin zabelana ngeempawu ezininzi kwaye zombini zinokuba luncedo kunyango lwe-2 yeswekile.
Nangona kunjalo, ukuba ugqirha umisela i-metformin emntwini, akufanele bathathe i-berberine njengenye indlela ngaphandle kokuxoxa ngayo nogqirha wabo kuqala.
Oogqirha baya kumisela idosi echanekileyo ye-metformin kumntu ngokusekelwe kwizifundo zeklinikhi. Akunakwenzeka ukwazi ukuba izongezo zihambelana njani nale mali.
I-Berberine inokunxibelelana ne-metformin kwaye ichaphazele iswekile yegazi lakho, isenza kube nzima ukuyilawula. Kuphononongo olunye, ukuthatha i-berberine kunye ne-metformin kunye kunciphisa iziphumo ze-metformin ngama-25%.
I-Berberine ngenye imini inokuba yinto efanelekileyo kwi-metformin yokulawula iswekile yegazi, kodwa uphando olungakumbi luyafuneka.
Iziko leSizwe leMpilo eFanelekileyo kunye neNtsebenziswano (NCCIH) ithi i-goldenrod, equkethe i-berberine, ayinakwenzeka ukuba ibangele imiphumo emibi kwixesha elifutshane ukuba abantu abadala bayithatha ngomlomo. Nangona kunjalo, akukho lwazi lwaneleyo lokubonisa ukuba ikhuselekile ekusebenziseni ixesha elide.
Kwizifundo zezilwanyana, izazinzulu ziqaphele ezi ziphumo zilandelayo ngokuxhomekeke kuhlobo lwesilwanyana, isixa kunye nexesha lolawulo:
Kubalulekile ukuthetha nogqirha wakho ngaphambi kokuba uthathe i-berberine okanye ezinye izongezo njengoko zingakhuselekanga kwaye zingafanelanga wonke umntu. Nabani na ochasayo kuyo nayiphi na imveliso yemifuno kufuneka ayeke ukuyisebenzisa ngokukhawuleza.