Umhlaza wemiphunga lolona hlobo lomhlaza luxhaphakileyo lwesibini kwihlabathi. Ngo-2020, bangaphezulu kwezigidi ezi-2.2 abantu kwihlabathi liphela abaza kufunyaniswa ukuba banomhlaza wemiphunga okokuqala ngqa. Kwangaloo nyaka, bamalunga ne-1.8 lesigidi abantu ehlabathini lonke ababulawa ngumhlaza wemiphunga.
Ngelixa okwangoku alukho unyango lomhlaza wemiphunga, oosonzululwazi basebenza kukhetho lonyango. Ezinye zezi nzululwazi zisebenza kwiYunivesithi yeThekhinoloji yaseSydney (UTS), apho uphando olutsha lubonise ukuba isityalo sendalo esibizwa ngokuba yi-berberine sinokunqanda ukukhula kweeseli zomhlaza wemiphunga kwilabhoratri.
I-Berberine sisityalo sesityalo esivela ngokwemvelo esiye sasetyenziswa kumayeza emveli aseTshayina kangangamawaka eminyaka. Ifumaneka kwiintlobo ngeentlobo zezityalo, kuquka i-barberry, i-goldenseal, i-Oregon yamagilebhisi, kunye ne-tree turmeric.

(Imveliso yethuBerberine Extract, wamkelekile ngokunyanisekileyo ukubuza.)

Iminyaka yophando ibonise ukuba i-berberine iyasebenza ekuncedeni abantu abanesifo sikashukela sohlobo lwe-2 ukulawula amanqanaba eswekile yegazi kwaye inokunceda ukunyanga isifo se-metabolic syndrome.
Abaphandi baye bafumanisa ukuba i-berberine ingasetyenziselwa ukunyanga iintlobo zomhlaza, kuquka i-ovarian, isisu kunye nomhlaza webele.
Ngokutsho kukaGqr. Kamal Dua, uMhlohli oMkhulu kunye noPhando oluPhezulu kwi-Pharmacy kwiZiko loPhando lwase-Australia kwi-Complementary and Integrative Medicine (ARCCIM), iYunivesithi yeThekhnoloji yaseSydney (UTS) yeSikolo sezoNyango kunye nombhali okhokelayo wokufunda, iBerberine inqanda ezimbini eziphambili. iinkqubo ekuphuhliseni umhlaza - Ukwanda kunye nokufuduka kweeseli.
"Ngoomatshini, oku kunokufezekiswa ngokuthintela iijini eziphambili ezifana ne-P53, i-PTEN kunye ne-KRT18 kunye neeprotheni ezifana ne-AXL, CA9, ENO2, HER1, HER2, HER3, PRGN, PDGF-AA, DKK1, CTSB, CTSD, BCLX, CSF1. kunye neCAPG ehambelana nokwanda kunye nokufuduka kweeseli zomhlaza, "wachaza.
Kuphononongo lwangoku, iqela lophando elibandakanya uDkt Dua, uDkt. Keshav Raj Paudel, uProfesa Philip M. Hansbrough kunye noDkt Bikash Manandhar we-UTS, kunye nabasebenzi baseMalaysian International Medical University kunye neYunivesithi yaseAl Qasim eSaudi Arabia, wafunda indlela iberberine enokusetyenziswa ngayo kunyango lomhlaza wemiphunga.
"Ukusetyenziswa kweklinikhi ye-berberine kulinganiselwe ngenxa ye-solubility yayo embi kunye ne-bioavailability," kuchaza uDkt Dua we-MNT. "Injongo ephambili yolu phononongo kukuphucula imilinganiselo ye-physicochemical ye-berberine ngokuguqula i-berberine ibe yi-crystal nanoparticles engamanzi kunye nokuphonononga amandla ayo e-anticancer kwi-vitro kwiiseli ze-alveolar epithelial basal ze-adenocarcinoma A549 yabantu."
Iqela lophando liphuhlise inkqubo yokuhanjiswa kweziyobisi ephucukileyo efaka i-berberine kumanqwanqwa amancinci anyibilikayo kunye ne-biodegradable. Ezi nanoparticles zekristale zolwelo zisetyenziselwe ukunyanga iiseli zomhlaza wemiphunga yomntu kwi-vitro elabhoratri.
Ekupheleni kophononongo, iqela lafumanisa ukuba i-berberine yanceda ukuvimba ukuveliswa kweentlobo ze-oksijeni ezisebenzayo, iikhemikhali ezivuthayo eziveliswa ngamaseli athile ekuphenduleni ukuhlasela kwebhaktheriya kunye nezinye iziganeko ezixinzelelekileyo ezinokulimaza iiseli.
Ukongeza, i-berberine inceda ukulawula izakhi zofuzo ezinxulumene noxinzelelo lwe-oxidative kunye nokudumba, kwaye inceda ekunciphiseni ukuguga kweseli kwangaphambi kwexesha.
"Siye sabonisa ukuba, ngokusebenzisa indlela ye-nanotechnological, iipropati ze-compound zinokuphuculwa ukujongana nemiba eyahlukeneyo enxulumene ne-solubility, i-cell uptake, kunye nempumelelo yonyango," kuchaza uDkt Dua. I-Anticancer Potential I-berberine liquid crystal nanoparticles yethu ibonise umsebenzi ofanayo ngamaxesha amahlanu idosi xa kuthelekiswa noncwadi olupapashiweyo, ebonisa ngokucacileyo izibonelelo ze-nanodrugs. "
Ukuqhubela phambili ukuvavanya ezi ziphumo, uGqr. Dua uthe uceba ukusebenzisa iqonga elitsha lophando ukuze aqhube izifundo ezinzulu esebenzisa imizekelo yezilwanyana ze-preclinical zomhlaza wemiphunga.
"Uphononongo olongezelelweyo lwe-pharmacokinetic kunye ne-anticancer ye-berberine nanodrugs kwiimodeli zezilwanyana kwi-vivo zingabonisa iinzuzo zabo ezinokuthi zifumane unyango lomhlaza wemiphunga kwaye ziguqule zibe ziifom ze-dosage yonyango," wachaza.
"Emva kokuba siqinisekisile amandla okulwa nomhlaza we-berberine nanodrugs kwiimodeli zezilwanyana zangaphambili, isinyathelo esilandelayo siya kufudukela kwiimvavanyo zekliniki, esele sixoxisana nenani leenkampani zaseSydney," kusho uDkt Dua.
Ukongeza, uGqr Dua wathi amandla e-berberine okuthintela ukuphindaphinda komhlaza wemiphunga kufuneka aqinisekiswe: "Nangona singakhange siyiphande le nto, siceba ukuyifunda kwizifundo ezizayo, kwaye sikholelwa ukuba i-berberine nanoforms iya kubonisa. umsebenzi othembisayo. “.
UGqr Osita Onuga, ugqirha we-thoracic kunye noprofesa oncedisayo wotyando lwe-thoracic kwi-St. John Cancer Institute kwi-Providence St. John Medical Centre eSanta Monica, eCalifornia, utshele i-MNT ukuba xa abaphandi befumana amathuba amatsha okunyanga nokukhusela umhlaza, kukho rhoqo. ithemba:
“IBerberine yinxalenye yeyeza laseMpuma, ngoko ke ngokwesiko asiyisebenzisi kumayeza aseNtshona. Ndicinga ukuba inomdla kuba sijonga into esiyaziyo ukuba ineenzuzo ezithile kwizinto zamayeza aseMpuma, kwaye uyibeke kuphando ukunceda ukuguqulela oko kwiyeza laseNtshona. “.
“Ihlala ithembisa, kodwa iselebhu, kwaye uninzi lwezinto esizifumana kwilebhu azikhokeleli ekubeni izigulana zinyangwe,” uqhubeke watsho u-Onuga. "Ndicinga ukuba into elandelayo ekufuneka yenziwe kukwenza ulingo lwezonyango kwizigulana kwaye ufumanise umthamo."
Abanye abantu bafumana iimpawu ezifihlakeleyo zomhlaza wemiphunga kwizigaba zokuqala zesi sifo. Funda ngakumbi ukuze ufunde ngakumbi, kubandakanywa ixesha lokubona ugqirha.
Umhlaza wemiphunga uvela ngamazinga ahlukeneyo kwabasetyhini kunye namadoda, kodwa iimpawu kunye neemeko zomngcipheko ziyafana. Apha sichaza ufuzo olunokwenzeka kunye nehomoni…
Singumenzi wesityalo esinobuchwephesha bokukhupha umgubo, wamkelekile ukuba sikuthumelele nayiphi na imibuzo malunga nemveliso yethu kwaye sinogxa wethu onoxanduva lokusombulula iingxaki zakho malunga nokuthengisa kwangaphambili kunye nasemva kokuthengisa. Qhagamshelana Nathi Naliphi na Ixesha!!!