Umhlaza wemiphunga lolona hlobo lwesibini oluxhaphakileyo lomhlaza ehlabathini. Ngowama-2020, abantu abangaphezu kwezigidi ezi-2.2 kwihlabathi liphela baza kufunyaniswa benomhlaza wemiphunga okokuqala. Kunyaka ofanayo, malunga nezigidi ezili-1.8 zabantu babulawa ngumhlaza wemiphunga kwihlabathi liphela.
Nangona okwangoku kungekho nyango lomhlaza wemiphunga, izazinzulu zisebenza kwiindlela zonyango. Abanye baba sosayensi basebenza kwiYunivesithi yeTekhnoloji eSydney (UTS), apho uphando olutsha lubonise ukuba isityalo sendalo esibizwa ngokuba yi-berberine sinokumisa ukukhula kweeseli zomhlaza wemiphunga kwilebhu.
I-Berberine yimveliso yezityalo eyenzeka ngokwendalo ebisetyenziswa kumayeza emveli aseTshayina kangangeminyaka engamawaka. Ifumaneka kwiintlobo ngeentlobo zezityalo, kuquka i-barberry, i-goldenseal, idiliya yase-Oregon, kunye ne-tree turmeric.

(Imveliso yethuIsicatshulwa seBerberine, wamkelekile ngokunyanisekileyo kwimibuzo.)

Iminyaka yophando ibonise ukuba i-berberine iyasebenza ekuncedeni abantu abanesifo seswekile sohlobo lwesibini ukulawula amanqanaba eswekile yegazi kwaye inokunceda ekunyangeni isifo se-metabolic syndrome.
Abaphandi bafumanise ukuba i-berberine ingasetyenziselwa ukunyanga iintlobo ngeentlobo zomhlaza, kuquka umhlaza wesibeleko, isisu, kunye nomhlaza webele.
Ngokutsho kukaGqr. Kamal Dua, uMhlohli oPhezulu kunye noMfundi oPhezulu woPhando kwiKhemesti kwiZiko loPhando lwase-Australia leMithi eNcedisayo neHlanganisayo (i-ARCCIM), iYunivesithi yeTekhnoloji yaseSydney (UTS) School of Medicine kunye nombhali ophambili wolu phando, iBerberine ithintela iinkqubo ezimbini ezibalulekileyo ekuphuhlisweni komhlaza - ukwanda kunye nokufuduka kweeseli.
“Ngokomatshini, oku kunokufezekiswa ngokuthintela iijini eziphambili ezifana ne-P53, i-PTEN kunye ne-KRT18 kunye neeproteni ezifana ne-AXL, i-CA9, i-ENO2, i-HER1, i-HER2, i-HER3, i-PRGN, i-PDGF-AA, i-DKK1, i-CTSB, i-CTSD, i-BCLX, i-CSF1. kunye ne-CAPG enxulumene nokwanda kunye nokufuduka kweeseli zomhlaza,” ucacisile.
Kolu phononongo lwangoku, iqela lophando eliquka uGqr. Dua, uGqr. Keshav Raj Paudel, uNjingalwazi uPhilip M. Hansbrough kunye noGqr. Bikash Manandhar we-UTS, kunye nabasebenzi abavela kwiYunivesithi yezonyango yaseMalaysian International kunye neYunivesithi yaseAl Qasim eSaudi Arabia, bafunde indlela i-berberine engasetyenziswa ngayo kunyango lomhlaza wemiphunga.
“Ukusetyenziswa kwe-berberine ngokwezonyango kunqongophele ngenxa yokunyibilika kwayo okuncinci kunye nokufumaneka kwayo kwi-bioavailability,” ucacise watsho uGqr. Dua we-MNT. “Injongo ephambili yolu phononongo kukuphucula iiparameter ze-physicochemical ze-berberine ngokuguqula i-berberine ibe yi-liquid crystal nanoparticles kunye nokuhlola amandla ayo okulwa nomhlaza kwi-vitro kwiiseli ze-alveolar epithelial basal ze-human adenocarcinoma A549.”
Iqela lophando liphuhlise inkqubo yokuhambisa amayeza ephucukileyo ehlanganisa i-berberine kwiindawo ezincinci ezinyibilikayo nezibolayo. Ezi nanoparticles zekristale yolwelo zisetyenziselwe ukunyanga iiseli zomhlaza wamaphaphu zomntu kwi-vitro kwilebhu.
Ekupheleni kophando, iqela lifumanise ukuba i-berberine incede ekuthinteleni ukuveliswa kweentlobo zeoksijini ezisebenzayo, iikhemikhali ezivuthayo eziveliswa ziiseli ezithile ukuphendula ukuhlasela kweebhaktheriya kunye nezinye iziganeko ezixinzelelekileyo ezinokonakalisa iiseli.
Ukongeza, i-berberine inceda ekulawuleni iijini ezinxulumene noxinzelelo lwe-oxidative kunye nokuvuvukala, kwaye inceda ekunciphiseni ukuguga kweeseli ngaphambi kwexesha.
“Sibonise ukuba, sisebenzisa indlela ye-nanotechnology, iipropati zekhompawundi zinokuphuculwa ukuze kujongwane nemiba eyahlukeneyo enxulumene nokunyibilika, ukufunxwa kweeseli, kunye nokusebenza kakuhle konyango,” ucacisile uGqr. Dua. I-Anticancer Potential Ii-nanoparticles zethu ze-berberine liquid crystal zibonise umsebenzi ofanayo ngokuphindwe kahlanu kwidosi xa kuthelekiswa noncwadi olushicilelweyo, nto leyo ebonisa ngokucacileyo iingenelo ze-nanodrugs.”
Ukuze aqhubeke nokuvavanya ezi ziphumo, uGqr. Dua uthe uceba ukusebenzisa iqonga elitsha lophando ukwenza uphando olunzulu esebenzisa iimodeli zezilwanyana zomhlaza wemiphunga ngaphambi konyango.
“Uphando olongezelelekileyo lwe-pharmacokinetic kunye nolwe-anticancer lwe-berberine nanodrugs kwiimodeli zezilwanyana ezikwi-vivo lunokubonisa iingenelo zazo kunyango lomhlaza wemiphunga kwaye luziguqule zibe ziifom zomthamo zonyango,” ucacisile.
“Nje ukuba siqinisekisile ukuba amayeza e-berberine nanodrugs anamandla okulwa nomhlaza kwiimodeli zezilwanyana zangaphambi konyango, inyathelo elilandelayo liza kuba kukuya kwiimvavanyo zeklinikhi, esisele sizixoxa ngazo neenkampani ezininzi zaseSydney,” utshilo uGqr. Dua.
Ukongeza, uGqr. Dua uthe amandla e-berberine okuthintela ukuphinda kuvele umhlaza wemiphunga kufuneka aqinisekiswe: “Nangona singakayiphandi le nto, siceba ukuyifundisisa kwizifundo ezizayo, kwaye sikholelwa nokuba ii-nanoforms ze-berberine ziya kubonisa umsebenzi othembisayo.”
UGqr. Osita Onuga, ugqirha wesifuba kunye noprofesa oncedisayo wotyando lwesifuba kwiSt. John Cancer Institute eProvidence St. John Medical Center eSanta Monica, eCalifornia, uxelele i-MNT ukuba xa abaphandi befumana amathuba amatsha okunyanga nokuthintela umhlaza, kusoloko kukho ithemba:
"I-Berberine yinxalenye yezonyango zaseMpuma, ngoko ke asiyisebenzisi ngokwesiko kunyango lwaseNtshona. Ndicinga ukuba inomdla kuba sijonga into esiyaziyo ukuba ineenzuzo ezithile kwizinto zonyango lwaseMpuma, kwaye siyifake kuphando ukuze incede ekuguquleleni oko kunyango lwaseNtshona."
“Ihlala ithembisa, kodwa ikwilebhu, kwaye uninzi lwezinto esizifumanayo kwilebhu azikhokeleli ekubeni izigulana zinyangwe,” uqhube watsho u-Onuga. “Ndicinga ukuba into elandelayo ekufuneka yenziwe kukwenza iimvavanyo zeklinikhi kwizigulana size sifumane idosi.”
Abanye abantu bafumana iimpawu ezingabonakaliyo zomhlaza wemiphunga kwisigaba sokuqala sesi sifo. Qhubeka ufunda ukuze ufumane ulwazi oluthe kratya, kuquka nexesha lokubonana nogqirha.
Umhlaza wemiphunga uvela ngamanqanaba ahlukeneyo kubasetyhini nakumadoda, kodwa iimpawu kunye nezinto ezinobungozi ziyafana. Apha sichaza i-genetic kunye ne-hormone ezinokwenzeka…
Singumvelisi weemveliso zezityalo ezikhupha umgubo, wamkelekile ukuba sikuthumelele nayiphi na imibuzo malunga nemveliso yethu kwaye sinomntu onoxanduva lokusombulula iingxaki zakho malunga nokuthengiswa kwangaphambili kunye nokuthengiswa emva kokuthengiswa. Qhagamshelana Nathi Nanini na!!!