I-supplement ebizwa ngokuba yi-5-hydroxytryptophan (5-HTP) okanye i-osetriptan ithathwa njengenye yonyango olulolunye lwentloko kunye ne-migraines.Umzimba uguqula le nto ibe yi-serotonin (5-HT), eyaziwa ngokuba yi-serotonin, i-neurotransmitter elawula isimo sengqondo kunye neentlungu.
Amanqanaba asezantsi e-serotonin aqhele ukubonwa kubantu abanokudakumba, kodwa abantu abane-migraine kunye nabo banentloko engapheliyo banokufumana amanqanaba asezantsi e-serotonin ngexesha naphakathi kohlaselo.Akucaci ukuba kutheni i-migraines kunye ne-serotonin zidibene.Eyona thiyori idumileyo yeyokuba ukunqongophala kwe-serotonin kwenza abantu bazive bebuhlungu kakhulu.
Ngenxa yolu nxibelelwano, iindlela ezininzi zokwandisa umsebenzi we-serotonin kwingqondo ziqhele ukusetyenziswa ukukhusela i-migraines kunye nokunyanga uhlaselo olubukhali.
I-5-HTP i-amino acid eyenziwe ngumzimba kwi-amino acid efunekayo i-L-tryptophan kwaye kufuneka ifunyenwe ekudleni.I-L-tryptophan ifumaneka kukutya okufana nembewu, iimbotyi zesoya, iturkey kunye noshizi.I-Enzymes ngokwemvelo iguqula i-L-tryptophan ibe yi-5-HTP, ethi emva koko iguqule i-5-HTP ibe yi-5-HT.
I-5-HTP izongezo zenziwe kwisityalo samayeza saseNtshona Afrika i-Griffonia simplicifolia.Esi songezelelo sisetyenziselwe ukunyanga ukudakumba, i-fibromyalgia, isifo esingapheliyo sokukhathala, kunye nokulahlekelwa kwesisindo, kodwa akukho bungqina obucacileyo beenzuzo zayo.
Xa uqwalasela i-5-HTP okanye nayiphi na isongezelelo sendalo, kubalulekile ukuqonda ukuba ezi mveliso ziyimichiza.Ukuba uwathatha ngenxa yokuba anamandla ngokwaneleyo ukuba abe nefuthe elihle kwimpilo yakho, khumbula ukuba anokuba namandla ngokwaneleyo ukuba abe nemiphumo emibi.
Akucaci ukuba izongezo ze-5-HTP zinenzuzo kwi-migraines okanye ezinye iintlobo zeentloko.Ngokubanzi, uphando lulinganiselwe;ezinye izifundo zibonisa ukuba iyanceda, ngelixa ezinye zingabonakalisi siphumo.
Izifundo ze-Migraine zisebenzise iidosi ze-5-HTP ukusuka kwi-25 ukuya kwi-200 mg ngosuku kubantu abadala.Okwangoku akukho dosi ecacileyo okanye ecetyiswayo yolu longezelelo, kodwa kuyafaneleka ukuba uqaphele ukuba iidosi eziphezulu zihambelana nemiphumo emibi kunye nokusebenzisana kweziyobisi.
I-5-HTP inokusebenzisana namanye amayeza, kuquka i-carbidopa, esetyenziselwa ukunyanga isifo sika-Parkinson.Iyakwazi ukusebenzisana ne-triptans, i-SSRIs, kunye ne-monoamine oxidase inhibitors (i-MAOIs, enye iklasi ye-antidepressants).
I-Tryptophan kunye ne-5-HTP izongezelelo zingangcoliswa kunye ne-4,5-tryptophanione yendalo, i-neurotoxin eyaziwa ngokuba yi-Peak X. Iziphumo ezivuthayo ze-Peak X zingabangela intlungu ye-muscle, i-cramping kunye nomkhuhlane.Iziphumo zexesha elide zingabandakanya umonakalo wemisipha kunye nemithambo-luvo.
Ngenxa yokuba le khemikhali i-byproduct ye-chemical reaction kwaye kungekhona ukungcola okanye ukungcola, inokufumaneka kwizongezelelo nangona zilungiswe phantsi kweemeko ezicocekileyo.
Kubalulekile ukuxoxa ngokuthatha naziphi na izongezo kunye nogqirha wakho okanye usokhemisti ukuze uqiniseke ukuba zikhuselekile kuwe kwaye aziyi kusebenzisana namanye amayeza akho.
Gcina ukhumbule ukuba izongezo zokutya kunye nemifuno azizange ziqhube uphononongo olungqongqo kunye novavanyo njengamayeza athengiswayo kunye namayeza amiselweyo, okuthetha ukuba uphando oluxhasa ukusebenza kwabo kunye nokhuseleko lulinganiselwe okanye aluphelelanga.
Izongezo kunye namayeza endalo anokuba nomtsalane, ngakumbi ukuba awanazo iziphumo ebezingalindelekanga.Ngapha koko, amayeza endalo angqineke esebenza kwizigulo ezininzi.Kukho ubungqina bokuba izongezo ze-magnesium zinokunciphisa ukuphindaphinda kunye nobunzima bokuhlaselwa kwe-migraine.Nangona kunjalo, akucaci ukuba i-5-HTP inenzuzo kwi-migraines.
Horvath GA, Selby K, Poskitt K, et al.Abantakwenu abanamanqanaba asezantsi e-serotonin e-serotonin bahlakulela i-hemiplegic migraine, ukuxhuzula, i-spastic paraplegia eqhubekayo, ukuphazamiseka kwemizwelo, kunye ne-coma.Intloko ebuhlungu.2011;31(15):1580-1586.Inombolo: 10.1177/0333102411420584.
Aggarwal M, Puri V, Puri S. Serotonin kunye neCGRP kwi-migraine.Ann Neuroscience.2012;19(2):88–94.doi:10.5214/ans.0972.7531.12190210
I-Chauvel V, i-Moulton S, i-Chenin J. Iziphumo ezixhomekeke kwi-Estrogen ye-5-hydroxytryptophan ekusasazeni ukudakumba kwe-cortical kwiigundane: ukulinganisa ukusebenzisana kwe-serotonin kunye ne-ovarian hormone kwi-migraine aura.Intloko ebuhlungu.2018;38(3):427-436.Inombolo: 10.1177/0333102417690891
UVictor S., uRyan SV Amayeza okuthintela i-migraine kubantwana.Cochrane Database Syst Rev 2003;(4):CD002761.Inombolo: 10.1002/14651858.CD002761
Das YT, Bagchi M., Bagchi D., Preus HG Ukhuseleko lwe-5-hydroxy-L-tryptophan.Iileta kwi-toxicology.2004;150(1):111-22.doi:10.1016/j.toxlet.2003.12.070
U-Teri Robert Teri Robert ungumbhali, umfundisi wesigulane, kunye nommeli wesigulane okhethekileyo kwi-migraines kunye neentloko.