Umzimba wakho uyisebenzisa ukuvelisa i-serotonin, umthunywa weekhemikhali othumela imiqondiso phakathi kweeseli zemithambo-luvo.
I-serotonin ephantsi idibaniswe nokudandatheka, ukuxhalaba, ukuphazamiseka kokulala, ukufumana ubunzima, kunye nezinye iingxaki zempilo (1, 2).
Ukunciphisa umzimba kwandisa ukuveliswa kwamahomoni abangela indlala. Le mvakalelo eqhubekayo yendlala inokwenza ukulahleka kwesisindo kungazinzi kwixesha elide (3, 4, 5).
I-5-HTP inokuchasana nala mahomoni abangela indlala acinezela ukutya kwaye akuncede unciphise umzimba (6).
Kwisifundo esinye, izigulane ze-20 zesifo seswekile zabelwa ngokungenamkhethe ukufumana i-5-HTP okanye i-placebo kwiiveki ezimbini. Iziphumo zibonise ukuba abo bafumana i-5-HTP badla malunga ne-435 iikhalori ezimbalwa ngosuku xa kuthelekiswa neqela le-placebo (7).
Ngaphezu koko, i-5-HTP ngokuyinhloko icinezela i-carbohydrate, ehambelana nokulawulwa kwe-glycemic engcono (7).
Uphando oluninzi luye lwabonisa ukuba i-5-HTP yonyusa i-satiety kwaye ikhuthaza ukunciphisa umzimba kubantu abatyebileyo okanye abatyebileyo (8, 9, 10, 11).
Ukongezelela, izifundo zezilwanyana zibonise ukuba i-5-HTP inokunciphisa ukutya okugqithisileyo ngenxa yoxinzelelo okanye ukudandatheka (12, 13).
I-5-HTP inokusebenza ekwandiseni ukuhlutha, okunokukunceda ukuba utye kancinci kwaye unciphise umzimba.
Ngelixa oyena nobangela wokudakumba ungaziwa kakhulu, abanye abaphandi bakholelwa ukuba ukungalingani kwe-serotonin kunokuchaphazela isimo sakho sengqondo, okukhokelela kuxinzelelo (14, 15).
Enyanisweni, izifundo ezininzi ezincinci zibonise ukuba i-5-HTP inokunciphisa iimpawu zokudakumba. Nangona kunjalo, ababini kubo abazange basebenzise i-placebo ukuze bathelekise, nto leyo eyanciphisa ukuqinisekiswa kweziphumo zabo (16, 17, 18, 19).
Nangona kunjalo, uphando oluninzi lubonise ukuba i-5-HTP inefuthe elinamandla lokuchasa uxinzelelo xa lisetyenziswe ngokudibeneyo nezinye izinto okanye i-antidepressants kunokuba isetyenziswe yodwa (17, 21, 22, 23).
Ukongezelela, uphononongo oluninzi luye lwagqiba ukuba uphando oluphezulu oluphezulu luyafuneka ngaphambi kokuba i-5-HTP inokucetyiswa kunyango lokudakumba (24, 25).
I-5-HTP izongezelelo zandisa amanqanaba e-serotonin emzimbeni, onokukhulula iimpawu zokudakumba, ngakumbi xa zidibaniswa namanye ama-antidepressants okanye amayeza. Nangona kunjalo, uphando olungakumbi luyafuneka.
Ukuxhaswa kwe-5-HTP kunokuphucula iimpawu ze-fibromyalgia, ukuphazamiseka okubonakaliswa yintlungu yemisipha kunye namathambo kunye nobuthathaka jikelele.
Okwangoku akukho sizathu esaziwayo se-fibromyalgia, kodwa amanqanaba aphantsi e-serotonin adibaniswe nemeko (26Trusted Source).
Oku kukhokelela abaphandi ukuba bakholelwe ukuba ukunyusa amanqanaba e-serotonin kunye ne-5-HTP izongezo zinokunceda abantu abane-fibromyalgia (27).
Enyanisweni, ubungqina bokuqala bubonisa ukuba i-5-HTP inokuphucula iimpawu ze-fibromyalgia, kuquka intlungu ye-muscle, iingxaki zokulala, ukuxhalaba kunye nokukhathala (28, 29, 30).
Nangona kunjalo, akukho uphando olwaneleyo olwenziwayo ukwenza naziphi na izigqibo eziqinileyo malunga nokusebenza kwe-5-HTP ekuphuculeni iimpawu ze-fibromyalgia.
I-5-HTP yandisa amanqanaba e-serotonin emzimbeni, onokukhulula ezinye zeempawu ze-fibromyalgia. Nangona kunjalo, uphando olungakumbi luyafuneka.
I-5-HTP kuthiwa inceda ukunyanga i-migraines, uhlobo lwentloko oluhlala luhamba kunye ne-nausea okanye ukuphazamiseka okubonakalayo.
Nangona isizathu sabo esichanekileyo sixoxwa, abanye abaphandi bakholelwa ukuba babangelwa amanqanaba aphantsi e-serotonin (31, 32).
Uphononongo lwabantu be-124 luthelekisa amandla e-5-HTP kunye ne-methylergometrine, iyeza eliqhelekileyo le-migraine, ukukhusela intloko ye-migraine (33).
Uphononongo lufumene ukuba ukuthatha i-5-HTP imihla ngemihla kwiinyanga ezintandathu kuthintele okanye kunciphise kakhulu inani lokuhlaselwa kwe-migraine kwi-71% yabathathi-nxaxheba (33).
Kwesinye isifundo sabafundi be-48, i-5-HTP yanciphisa i-headache frequency nge-70% xa kuthelekiswa ne-11% kwiqela le-placebo (34).
Ngokufanayo, ezinye izifundo ezininzi zibonise ukuba i-5-HTP ingaba yonyango olusebenzayo lwe-migraines (30, 35, 36).
I-Melatonin idlala indima ebalulekileyo ekulawuleni ukulala. Amanqanaba ayo aqala ukunyuka ebusuku ukukhuthaza ukulala kunye nokuwa kusasa ukukunceda ukuba uvuke.
Ke ngoko, ukuxhaswa kwe-5-HTP kunokukhuthaza ubuthongo ngokwandisa imveliso ye-melatonin emzimbeni.
Uphononongo lwabantu lufumene ukuba ukudibanisa kwe-5-HTP kunye ne-gamma-aminobutyric acid (GABA) yanciphisa kakhulu ixesha elithathayo ukulala, ukunyuka kwexesha lokulala, kunye nokuphucula umgangatho wokulala (37).
I-GABA sisithunywa sekhemikhali esikhuthaza ukuphumla. Ukudibanisa kunye ne-5-HTP kunokuba nefuthe le-synergistic (37).
Enyanisweni, izifundo ezininzi zezilwanyana kunye nezinambuzane zibonise ukuba i-5-HTP iphucula umgangatho wokulala kwaye ingcono ngakumbi xa idibene ne-GABA (38, 39).
Nangona ezi ziphumo zithembisa, ukungabikho kwezifundo zabantu kwenza kube nzima ukucebisa i-5-HTP yokuphucula umgangatho wokulala, ngakumbi xa isetyenziswe yodwa.
Abanye abantu banokufumana isicaphucaphu, urhudo, ukugabha, kunye neentlungu zesisu ngelixa bethatha izongezo ze-5-HTP. Ezi ziphumo bezingalindelekanga zixhomekeke kwidosi, oku kuthetha ukuba ziya ziba mandundu njengoko umthamo unyuka (33).
Ukunciphisa le miphumo emibi, qalisa nge-dose ye-50-100 mg kabini imihla ngemihla kwaye unyuke ukuya kwidosi efanelekileyo kwiiveki ezimbini (40).
Amanye amayeza anyusa ukuveliswa kwe-serotonin. Ukudibanisa la mayeza kunye ne-5-HTP kunokubangela amanqanaba ayingozi e-serotonin emzimbeni. Oku kubizwa ngokuba yi-serotonin syndrome, imeko enokuba yingozi ebomini (41).
Amayeza anokunyusa amanqanaba e-serotonin emzimbeni aquka amayeza athile okudakumba, amayeza okhohlokhohlo, okanye amayeza okuthomalalisa iintlungu.
Ngenxa yokuba i-5-HTP inokukhuthaza ukulala, ukuyithatha kunye ne-sedatives ye-prescription efana ne-Klonopin, i-Ativan, okanye i-Ambien inokubangela ukozela kakhulu.
Ngenxa yokusebenzisana okungalunganga okunokwenzeka kunye namanye amayeza, jonga ugqirha wakho okanye usokhemisti ngaphambi kokuba uthathe izongezo ze-5-HTP.
Xa uthengela izongezo, khangela i-NSF okanye i-USP seal ebonisa umgangatho ophezulu. Ezi ziinkampani zeqela lesithathu eziqinisekisa ukuba izongezo ziqulethe oko kuchazwe kwileyibhile kwaye azinabumdaka.
Abanye abantu banokufumana iziphumo ebezingalindelekanga xa bethatha izongezo ze-5-HTP. Jonga ugqirha wakho phambi kokuba uthathe i-5-HTP ukuze uqiniseke ukuba ikhuselekile kuwe.
Ezi zongezelelo zihluke kwi-L-tryptophan supplements, ezinokunyusa amanqanaba e-serotonin (42).
I-L-tryptophan yi-amino acid ebalulekileyo efumaneka kukutya okuneprotheyini eninzi okufana nobisi, inkukhu, inyama, i-chickpeas kunye nesoya.
Ngakolunye uhlangothi, i-5-HTP ayifumanekanga ekutyeni kwaye inokongezwa kuphela kwisondlo sakho ngokusebenzisa izongezo zokutya (43).
Umzimba wakho uguqula i-5-HTP ibe yi-serotonin, into elawula ukutya, ukuqonda intlungu, kunye nokulala.
Amanqanaba aphezulu e-serotonin anokuba neenzuzo ezininzi, ezifana nokunciphisa umzimba, ukukhululeka kwiimpawu zokudakumba kunye ne-fibromyalgia, ukunciphisa ukuphindaphinda kokuhlaselwa kwe-migraine, kunye nokulala okungcono.
Iziphumo ezincinci ezincinci ziye zadibaniswa ne-5-HTP, kodwa ezi zinokuncitshiswa ngokuqala ngeedosi ezincinci kunye nokwandisa umthamo.
Ngenxa yokuba i-5-HTP inokunxibelelana kakubi namayeza athile, jonga ugqirha wakho ukuze uqiniseke ukuba ikhuselekile kuwe.
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