Umzimba wakho uyisebenzisela ukuvelisa i-serotonin, isithunywa sekhemikhali esithumela imiqondiso phakathi kweeseli zemithambo-luvo.
I-serotonin ephantsi inxulunyaniswa nokudakumba, ixhala, ukuphazamiseka kokulala, ukutyeba, kunye nezinye iingxaki zempilo (1, 2).
Ukunciphisa umzimba kwandisa imveliso yeehomoni ezibangela indlala. Olu luvo luhlala lukhona lwendlala lunokwenza ukunciphisa umzimba kungabi nakwenzeka ekuhambeni kwexesha (3, 4, 5).
I-5-HTP isenokulwa nezi hormone zibangela indlala ezithintela inkanuko kwaye zikuncede unciphise umzimba (6).
Kolunye uphando, izigulane ezingama-20 zeswekile zabelwa ngokungacwangciswanga ukuba zifumane i-5-HTP okanye i-placebo kangangeeveki ezimbini. Iziphumo zibonise ukuba abo bafumana i-5-HTP batya malunga neekhalori ezingama-435 ezimbalwa ngosuku xa kuthelekiswa neqela le-placebo (7).
Ngaphezu koko, i-5-HTP ithintela kakhulu ukutya iicarbohydrate, nto leyo enxulunyaniswa nolawulo olungcono lwe-glycemic (7).
Ezinye izifundo ezininzi zibonise ukuba i-5-HTP inyusa ukuhlutha kwaye ikhuthaza ukwehla kobunzima kubantu abatyebe kakhulu okanye abatyebe kakhulu (8, 9, 10, 11).
Ukongeza, izifundo zezilwanyana zibonise ukuba i-5-HTP inokunciphisa ukutya okugqithisileyo ngenxa yoxinzelelo okanye ukudakumba (12, 13).
I-5-HTP inokuba luncedo ekwandiseni ukuhlutha, nto leyo enokukunceda utye kancinci kwaye unciphise umzimba.
Nangona unobangela ochanekileyo woxinzelelo ungaziwa kakhulu, abanye abaphandi bakholelwa ukuba ukungalingani kwe-serotonin kunokuchaphazela indlela ovakalelwa ngayo, nto leyo ekhokelela kuxinzelelo (14, 15).
Enyanisweni, izifundo ezincinci ezininzi zibonise ukuba i-5-HTP inokunciphisa iimpawu zokudakumba. Nangona kunjalo, ezimbini kuzo azizange zisebenzise i-placebo xa zithelekiswa, nto leyo eyanciphisa ukufaneleka kweziphumo zazo (16, 17, 18, 19).
Nangona kunjalo, izifundo ezininzi zibonise ukuba i-5-HTP inefuthe elinamandla lokudakumba xa isetyenziswa kunye nezinye izinto okanye amayeza okudakumba kunaxa isetyenziswa yodwa (17, 21, 22, 23).
Ukongeza, uphononongo oluninzi lugqibe kwelokuba kufuneka uphando oluphezulu ngaphambi kokuba kucetyiswe i-5-HTP kunyango lokudakumba (24, 25).
Izongezo ze-5-HTP zonyusa amanqanaba e-serotonin emzimbeni, nto leyo enokunciphisa iimpawu zokudakumba, ingakumbi xa zidityaniswe nezinye izidambisi-ntlungu okanye amayeza. Nangona kunjalo, kufuneka uphando oluthe kratya.
Ukongezwa kwe-5-HTP kunokuphucula iimpawu ze-fibromyalgia, isifo esibonakaliswa ziintlungu zemisipha namathambo kunye nobuthathaka ngokubanzi.
Okwangoku akukho sizathu saziwayo se-fibromyalgia, kodwa amanqanaba aphantsi e-serotonin adibene nale meko (26Trusted Source).
Oku kukhokelela ekubeni abaphandi bakholelwe ukuba ukunyusa amanqanaba e-serotonin ngee-supplements ze-5-HTP kunokubanceda abantu abane-fibromyalgia (27).
Enyanisweni, ubungqina bokuqala bubonisa ukuba i-5-HTP inokunceda iimpawu ze-fibromyalgia, kuquka iintlungu zemisipha, iingxaki zokulala, ixhala, kunye nokudinwa (28, 29, 30).
Nangona kunjalo, uphando olunganelanga olwenziweyo ukuze kufunyanwe izigqibo eziqinileyo malunga nokusebenza kakuhle kwe-5-HTP ekuphuculeni iimpawu ze-fibromyalgia.
I-5-HTP yonyusa amanqanaba e-serotonin emzimbeni, nto leyo enokuphelisa ezinye zeempawu ze-fibromyalgia. Nangona kunjalo, kufuneka uphando oluthe kratya.
Kuthiwa i-5-HTP iyanceda ekunyangeni iintloko ezibuhlungu, uhlobo lwentloko ebuhlungu edla ngokuhamba nesicaphucaphu okanye ukuphazamiseka kokubona.
Nangona unobangela wazo usaxoxwa, abanye abaphandi bakholelwa ukuba zibangelwa ngamanqanaba aphantsi e-serotonin (31, 32).
Uphononongo lwabantu abali-124 luthelekise ubuchule be-5-HTP kunye ne-methylergometrine, iyeza eliqhelekileyo le-migraine, ukuthintela iintloko ezibuhlungu ze-migraine (33).
Uphononongo lufumanise ukuba ukuthatha i-5-HTP imihla ngemihla kangangeenyanga ezintandathu kuthintela okanye kunciphisa kakhulu inani lokuhlaselwa yi-migraine kwi-71% yabathathi-nxaxheba (33).
Kolunye uphando lwabafundi abangama-48, i-5-HTP inciphise ukuxhaphaka kwentloko ngama-70% xa kuthelekiswa ne-11% kwiqela le-placebo (34).
Ngokufanayo, ezinye izifundo ezininzi zibonise ukuba i-5-HTP inokuba lunyango olusebenzayo lwe-migraines (30, 35, 36).
I-Melatonin idlala indima ebalulekileyo ekulawuleni ubuthongo. Amanqanaba ayo aqala ukunyuka ebusuku ukuze akhuthaze ubuthongo kwaye awe kusasa ukuze akuncede uvuke.
Ngoko ke, ukongezwa kwe-5-HTP kunokukhuthaza ubuthongo ngokunyusa imveliso ye-melatonin emzimbeni.
Uphononongo lwabantu lufumanise ukuba indibaniselwano ye-5-HTP kunye ne-gamma-aminobutyric acid (GABA) inciphise kakhulu ixesha elithathwayo ukuze ulale, yandisa ixesha lokulala, kwaye iphucule umgangatho wokulala (37).
I-GABA sisithunywa sekhemikhali esikhuthaza ukuphumla. Ukuyidibanisa ne-5-HTP kunokuba nefuthe lokusebenzisana (37).
Enyanisweni, izifundo ezininzi zezilwanyana nezinambuzane zibonise ukuba i-5-HTP iphucula umgangatho wokulala kwaye ingcono nangakumbi xa idityaniswe neGABA (38, 39).
Nangona ezi ziphumo zithembisa, ukungabikho kwezifundo zabantu kwenza kube nzima ukucebisa i-5-HTP ukuphucula umgangatho wokulala, ingakumbi xa isetyenziswa yodwa.
Abanye abantu banokuba nesicaphucaphu, urhudo, ukuhlanza, kunye nentlungu yesisu ngelixa bethatha izongezo ze-5-HTP. Ezi ziphumo bezingalindelekanga zixhomekeke kwidosi, oko kuthetha ukuba ziya ziba mandundu njengoko idosi isanda (33).
Ukuze unciphise ezi ziphumo bezingalindelekanga, qala ngedosi ye-50–100 mg kabini ngemini uze uyinyuse iye kwidosi efanelekileyo kwiiveki ezimbini (40).
Amanye amayeza anyusa ukuveliswa kwe-serotonin. Ukudibanisa la mayeza ne-5-HTP kunokubangela amanqanaba ayingozi e-serotonin emzimbeni. Oku kubizwa ngokuba yi-serotonin syndrome, imeko enokuba yingozi ebomini (41).
Amayeza anokunyusa amanqanaba e-serotonin emzimbeni aquka amayeza athile okudakumba, amayeza okukhwehlela, okanye amayeza okunciphisa iintlungu abhalwe ngugqirha.
Ngenxa yokuba i-5-HTP isenokukhuthaza ukulala, ukuyithatha kunye neziyobisi ezithomalalisayo ezibhalwe ngugqirha ezifana neKlonopin, iAtivan, okanye iAmbien kunokubangela ukozela kakhulu.
Ngenxa yokuba kunokwenzeka ukuba kubekho unxibelelwano olubi namanye amayeza, jongana nogqirha wakho okanye nekhemisti ngaphambi kokuba uthathe izongezo ze-5-HTP.
Xa uthenga izongezo, khangela izitywino ze-NSF okanye ze-USP ezibonisa umgangatho ophezulu. Ezi ziinkampani zangaphandle eziqinisekisa ukuba izongezo ziqulathe oko kubhalwe kwileyibhile kwaye azinazo izinto ezingcolileyo.
Abanye abantu banokufumana iziphumo ebezingalindelekanga xa bethatha izongezo ze-5-HTP. Buza ugqirha wakho ngaphambi kokuba uthathe i-5-HTP ukuqinisekisa ukuba ikhuselekile kuwe.
Ezi zongezo zahlukile kwezongezo ze-L-tryptophan, ezinokunyusa amanqanaba e-serotonin (42).
I-L-tryptophan yi-amino acid ebalulekileyo efumaneka ekutyeni okuneproteni eninzi njengobisi, inkukhu, inyama, iitshizi kunye nesoya.
Kwelinye icala, i-5-HTP ayifumaneki ekutyeni kwaye inokongezwa kuphela ekutyeni kwakho ngezongezo zokutya (43).
Umzimba wakho uguqula i-5-HTP ibe yi-serotonin, into elawula ukutya, ukuqonda iintlungu kunye nokulala.
Amanqanaba aphezulu e-serotonin anokuba neenzuzo ezininzi, ezinje ngokunciphisa umzimba, ukukhululeka kwiimpawu zokudakumba kunye ne-fibromyalgia, ukuncipha kokuhlaselwa yi-migraine rhoqo, kunye nokulala ngcono.
Iziphumo ebezingalindelekanga ezincinci ziye zanxulunyaniswa ne-5-HTP, kodwa ezi zinokuncitshiswa ngokuqala ngeedosi ezincinci uze unyuse idosi kancinci kancinci.
Ekubeni i-5-HTP isenokungasebenzi kakuhle namayeza athile, jonga ugqirha wakho ukuqinisekisa ukuba ikhuselekile kuwe.
Iingcali zethu zihlala zijonga imeko yezempilo kunye nempilo-ntle kwaye zihlaziya amanqaku ethu njengoko kufumaneka ulwazi olutsha.
I-5-HTP isetyenziswa rhoqo njengesongezelelo sokunyusa amanqanaba e-serotonin. Ingqondo isebenzisa i-serotonin ukulawula imo yengqondo, ukutya, kunye neminye imisebenzi ebalulekileyo. kodwa…
IXanax inceda njani ekulweni noxinzelelo? IXanax isetyenziswa kakhulu ekunyangeni ixhala kunye neengxaki zoloyiko.