I-Arachidonic acid (ARA), i-docosahexaenoic acid (DHA) kunye ne-eicosapentaenoic acid (EPA) ngamatsheyini amade e-polyunsaturated fatty acids (LCPUFA). I-Carotenoids, kuquka i-lutein kunye ne-zeaxanthin (LZ), ifumaneka kakhulu kwimifuno eluhlaza.
I-ARA kunye ne-DHA zininzi kwingqondo kwaye ziyinxalenye enkulu ye-phospholipids. Uphononongo lubonise ukuba ukongeza ngeedosi eziphezulu ze-DHA kunye ne-EPA kunokuphucula ukusebenza kwememori kubantu abadala.
Ukongezelela, i-LZ, i-antioxidant component yengqondo, kuye kwabikwa ukuba inempembelelo yokukhusela kwiiseli ze-nerve, ngaloo ndlela ichaphazela umsebenzi wokuqonda. Nangona kunjalo, ukusebenza kwe-lutein kunye ne-zeaxanthin kumsebenzi wememori akucaci ngenxa yeziphumo eziphikisanayo ezivela kwizifundo zongenelelo zangaphambili.
Ngokusekelwe kwinto yokuba i-ARA, i-DHA, i-EPA, i-L kunye ne-Z (i-LCPUFA + LZ) ikhona kwingqondo, kunye nezinye iingxelo zokuphucula umsebenzi wememori, ababhali bophononongo lwangoku bacebisa ukuba ukudibanisa kwezi zinto kunokuphucula. inkumbulo. ukusebenza kwengqondo. abantu abadala abasempilweni.
Abaphandi baseJapan baqhube i-24-iveki, i-randomized, i-double-blind, i-placebo-controlled, isifundo seqela elihambelanayo leempembelelo ze-LCPUFA + LH kumsebenzi wememori kubantu abadala baseJapan abanempilo abaneengxaki zememori kodwa ngaphandle kokuphazamiseka kwengqondo.
Abafumananga mahluko ubalulekileyo phakathi kwamaqela. Nangona kunjalo, kuhlalutyo oludibeneyo lweqela labathathi-nxaxheba abanokuncipha kwengqondo, ukuphuculwa okuphawulekayo kwabonwa.
Le ngxelo iqukumbela ngelithi: “Olu phononongo lubonisa okokuqala ukuba indibaniselwano yeLCPUFA kunye ne-LZ inokuphucula ukusebenza kwenkumbulo kubantu abadala baseJapan abasempilweni nabanokuncipha kwengqondo kodwa ngaphandle kokuphazamiseka kwengqondo. 'isicatshulwa ad1′); });
Ingqikithi yabathathi-nxaxheba be-120 abavela eTokyo kunye nommandla ojikelezileyo bahlelwa ngamaqela amathathu: (1) iqela le-placebo elifumana indawo ye-placebo njengesongezelelo sokutya; (2) iqela le-placebo elifumana i-placebo njengesongezelelo sokutya; (2)). Iqela le-LCPUFA + X elifumene i-supplementary supplement equkethe i-LCPUFA (equlethe i-120 mg ARA, i-300 mg DHA kunye ne-100 mg EPA ngosuku) kunye ne-Compound X (engaboniswanga njengoko le ngqungquthela yayingeyona nto yolu phononongo) ) (3) LCPUFA + Iqela le-LH elifumana isongezelelo sokutya esibandakanya i-LCPUFA (120mg ARA, 300mg DHA kunye ne-100mg EPA ngosuku) ngokudibanisa ne-LH (10mg lutein kunye ne-2mg zeaxanthin ngosuku).
Ukutya okuvavanywayo kunye nokubonelela kolu phononongo kunikezelwe yiSuntory Health Co., Ltd., ethengisa ukutya okunempilo okuqukethe iLCPUFA.
I-Wechsler Logical Memory Scale II ehlaziyiweyo (i-WMS-R LM II) kunye ne-Montreal Cognitive Test ngesiJapan (i-MoCA-J) yasetyenziselwa ukuhlolwa.
Ubudala, isini, kunye nemfundo zabhalwa njengeempawu zabathathi-nxaxheba. Iisampuli zegazi ziqokelelwe kwisiseko, iiveki ze-12 kunye ne-24 ye-fatty acid kunye nohlalutyo lwe-LZ.
Uvavanyo lwe-neuropsychological lwenziwa kwaye i-fatty fat acid intake yalinganiswa kwisiseko, kwii-12 kunye neeveki ze-24. Umthathi-nxaxheba ngamnye ugqibe idayari, erekhoda ukutya okongeziweyo kunye nokujonga utshintsho olukhulu lwendlela yokuphila.
Iziphumo zabonisa ukuba i-LCPUFA + LZ yayingenayo impembelelo ebalulekileyo ekusebenzeni kwememori kubantu abadala baseJapan abanempilo abaneengxaki zememori, kodwa isongezelelo siye saphucula umsebenzi wememori kubathathi-nxaxheba abanokuncipha kwengqondo.
Ababhali bathi izifundo zongenelelo ezizayo ezisekelwe kulwazi olucacileyo lwesiseko sokusebenza kwengqondo kwabathathi-nxaxheba kuya kunceda ukwenza izigwebo ezifanelekileyo malunga nomphumo wokungenelela kumsebenzi wememori.
"Impembelelo ye-long-chain polyunsaturated fatty acids kudityaniswa ne-lutein kunye ne-zeaxanthin kwimemori ye-episodic kubantu abadala abasempilweni"
Sueyasu, T., Yasumoto, K., Tokuda, H., Kaneda, Y.;
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