I-Arachidonic acid (ARA), i-docosahexaenoic acid (DHA) kunye ne-eicosapentaenoic acid (EPA) zii-polyunsaturated fatty acids ezinde (LCPUFA). Ii-Carotenoids, kuquka i-lutein kunye ne-zeaxanthin (LZ), zifumaneka kakhulu kwimifuno eluhlaza.
I-ARA kunye ne-DHA zininzi engqondweni kwaye zezona zinto ziphambili kwi-phospholipids. Izifundo zibonise ukuba ukongeza iidosi eziphezulu ze-DHA kunye ne-EPA kunokuphucula ukusebenza kwememori kubantu abadala.
Ukongeza, i-LZ, icandelo le-antioxidant lobuchopho, kuye kwaxelwa ukuba linefuthe lokukhusela kwiiseli zemithambo-luvo, ngaloo ndlela lichaphazela ukusebenza kwengqondo. Nangona kunjalo, ukusebenza kakuhle kwe-lutein kunye ne-zeaxanthin ekusebenzeni kwenkumbulo akucaci ngenxa yeziphumo eziphikisanayo ezivela kwizifundo zokungenelela zangaphambili.
Ngokusekelwe kwinto yokuba i-ARA, i-DHA, i-EPA, i-L kunye ne-Z (i-LCPUFA + i-LZ) zikhona engqondweni, kunye neengxelo ezithile zomsebenzi ophuculweyo wenkumbulo, ababhali bolu phononongo lwangoku bacebise ukuba ukudibana kwezi zinto kunokuphucula umsebenzi wenkumbulo. abantu abadala abasempilweni.
Abaphandi baseJapan benze uphando lweeveki ezingama-24, olucwangcisiweyo, olungaboni kabini, olulawulwa yi-placebo, nolulawulwa ngamaqela ngaxeshanye malunga nemiphumo ye-LCPUFA + LH ekusebenzeni kwememori kubantu abadala baseJapan abasempilweni abaneengxaki zememori kodwa abangenayo i-dementia.
Abafumananga mahluko abalulekileyo phakathi kwamaqela. Nangona kunjalo, kuhlalutyo oludibeneyo lweqela labathathi-nxaxheba abanokwehla kwengqondo, kubonwe uphuculo olubalulekileyo.
Ingxelo iphetha ngelithi: “Olu phononongo lubonisa okokuqala ukuba indibaniselwano ye-LCPUFA kunye ne-LZ inokuphucula ukusebenza kwenkumbulo kubantu abadala baseJapan abasempilweni abanokwehla kwengqondo kodwa abangenayo i-dementia.” 'text ad1′); });
Abathathi-nxaxheba abali-120 abavela eTokyo nakwiindawo ezingqongileyo bahlelwe ngokwamaqela amathathu: (1) iqela le-placebo elifumana i-placebo njengesongezelelo sokutya; (2) iqela le-placebo elifumana i-placebo njengesongezelelo sokutya; (2)). Iqela le-LCPUFA+X elifumene isongezelelo sokutya esiquka i-LCPUFA (equlethe i-120 mg ye-ARA, i-300 mg ye-DHA kunye ne-100 mg ye-EPA ngosuku) kunye neCompound X (ayiboniswanga njengoko le compound yayingengomxholo wolu phononongo) ) (3) Iqela le-LCPUFA+LH elifumana isongezelelo sokutya esiquka i-LCPUFA (120mg ye-ARA, 300mg ye-DHA kunye ne-100mg ye-EPA ngosuku) kunye ne-LH (10mg ye-lutein kunye ne-2mg ye-zeaxanthin ngosuku).
Ukutya okulingwayo kunye nezinto ezifunekayo kolu phononongo zibonelelwe yiSuntory Health Co., Ltd., ethengisa ukutya okunempilo okuqulethe i-LCPUFA.
I-Wechsler Logical Memory Scale II ehlaziyiweyo (WMS-R LM II) kunye neMontreal Cognitive Test ngesiJapani (MoCA-J) zisetyenziselwe ukuhlola.
Ubudala, isini, kunye nemfundo zibhalwe njengeempawu zabathathi-nxaxheba. Iisampuli zegazi zaqokelelwa ekuqaleni, kwiiveki ze-12 kunye ne-24 ukuze kuhlolwe i-fatty acid kunye ne-LZ.
Kwenziwe uvavanyo lwe-neuropsychological kwaye ukutya okunamafutha acid kwalinganiswa ekuqaleni, kwiiveki ezili-12 nezingama-24. Umthathi-nxaxheba ngamnye ugqibezele idayari, erekhoda ukutya okongezelelweyo aze ajonge utshintsho olukhulu kwindlela yokuphila.
Iziphumo zibonise ukuba i-LCPUFA + LZ ayinampembelelo ibalulekileyo ekusebenzeni kwememori kubantu abadala baseJapan abasempilweni abaneengxaki zememori, kodwa eso songezo siphucule ukusebenza kwememori kubantu abachaphazelekileyo kukungaqondi kakuhle kwengqondo.
Ababhali bathi izifundo zokungenelela kwixesha elizayo ezisekelwe kulwazi oluneenkcukacha malunga nokusebenza kwengqondo okusisiseko kwabathathi-nxaxheba ziya kunceda ekwenzeni izigqibo ezifanelekileyo malunga nempembelelo yokungenelela kumsebenzi wememori.
"Isiphumo se-polyunsaturated fatty acids ezinde kunye ne-lutein kunye ne-zeaxanthin kwimemori ye-episodic kubantu abadala abasempilweni"
Sueyasu, T., Yasumoto, K., Tokuda, H., Kaneda, Y.;
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