Kuphononongo olutsha, abaphandi bafumanise ukuba ichiza elitsha elisekwe kwinxalenye yembewu yomdiliya isicatshulwa linokwandisa ngempumelelo ubomi kunye nempilo yeempuku.
Uphononongo, olupapashwe kwijenali yeNdalo yeMetabolism, lubeka isiseko sezifundo ezongezelelweyo zeklinikhi ukufumanisa ukuba ezi ziphumo zinokuphinda ziphindwe ebantwini.
Ukuguga yeyona nto iphambili kumngcipheko wezifo ezininzi ezingapheliyo. Izazinzulu zikholelwa ukuba oku kungenxa yokuguga kweeseli. Oku kwenzeka xa iiseli zingasakwazi ukwenza imisebenzi yazo yebhayoloji emzimbeni.
Kwiminyaka yakutshanje, abaphandi baye bafumanisa iklasi yamachiza ebizwa ngokuba yi-senolytics. La machiza anokutshabalalisa iiseli ze-senescent kwi-laboratory kunye neemodeli zezilwanyana, ezinokuthi zinciphise iziganeko zezifo ezingapheliyo ezivela njengoko sikhula kwaye siphila ixesha elide.
Kolu phononongo, izazinzulu ziye zafumanisa i-senolytic entsha ephuma kwilungu lembewu yomdiliya ebizwa ngokuba yiproanthocyanidin C1 (PCC1).
Ngokusekwe kwidatha yangaphambili, i-PCC1 kulindeleke ukuba ithintele isenzo seeseli ze-senescent kwindawo ephantsi kwaye itshabalalise ngokukhetha iiseli ze-senescent kwiindawo eziphezulu.
Kuvavanyo lokuqala, baye baveza iimpuku kwiidosi ezingaphantsi kwemitha yemitha ukuphembelela ukuvela kweseli. Elinye iqela leempuku emva koko lafumana iPCC1, kwaye elinye iqela lafumana isithuthi esithwele iPCC1.
Abaphandi bafumanisa ukuba emva kokuba iimpuku zibonakaliswe kwimitha, ziye zavelisa iimpawu ezingaqhelekanga zomzimba, kuquka ubuninzi beenwele ezingwevu.
Unyango lweempuku nge-PCC1 lutshintshe kakhulu ezi mpawu. Iimpuku ezinikwe i-PCC1 nazo zineeseli zesenescent ezimbalwa kunye ne-biomarkers ezinxulumene neeseli zeseli.
Ekugqibeleni, iigundane ezifakwe kwi-irradiated zazinokusebenza okuncinci kunye namandla emisipha. Nangona kunjalo, imeko yatshintsha kwiigundane ezinikwe i-PCC1, kwaye zinezinga eliphezulu lokusinda.
Kuvavanyo lwesibini, abaphandi batofa iimpuku eziguga ngePCC1 okanye isithuthi rhoqo kwiiveki ezimbini kwiinyanga ezine.
Iqela lifumene inani elikhulu leeseli ze-senescent kwizintso, isibindi, imiphunga kunye ne-prostates yeempuku ezindala. Nangona kunjalo, unyango nge-PCC1 lwatshintsha imeko.
Iigundane eziphathwe nge-PCC1 nazo zibonise ukuphuculwa kwamandla okubamba, isantya esiphezulu sokuhamba, ukunyamezela ukuxhoma, ukunyamezela kwe-treadmill, inqanaba lomsebenzi wemihla ngemihla, kunye nokulinganisela xa kuthelekiswa neempuku ezifumene isithuthi sodwa.
Kuvavanyo lwesithathu, abaphandi bajonge iimpuku ezindala kakhulu ukubona ukuba iPCC1 ichaphazele ubomi babo.
Baye bafumanisa ukuba iigundane eziphathwe nge-PCC1 zihlala ixesha elide kune-9.4% kuneempuku eziphathwa ngesithuthi.
Ngaphezu koko, ngaphandle kokuhlala ixesha elide, iigundane eziphathwe nge-PCC1 azizange zibonise nakuphi na ukugula okuphezulu okunxulumene nobudala xa kuthelekiswa neempuku eziphathwe ngesithuthi.
Eshwankathela oko kufunyanisiweyo, umbhali ohambelanayo noNjingalwazi uSun Yu ovela kwiShanghai Institute of Nutrition and Health eTshayina noogxa bakhe wathi: “Ngoko sinika ubungqina bomgaqo-siseko wokuba [iPCC1] inamandla okulibazisa ngokuphawulekayo ukungasebenzi kakuhle okunxulumene nobudala naxa ithathwa.” kamva ebomini, inamandla amakhulu okunciphisa izifo ezinxulumene neminyaka kunye nokuphucula iziphumo zempilo, ngaloo ndlela ivula iindlela ezintsha zeyeza elizayo lokuphucula impilo kunye nokuphila ixesha elide. "
UGqr James Brown, ilungu le-Aston Centre for Healthy Aging e-Birmingham, e-UK, utshele i-Medical News Namhlanje ukuba iziphumo zibonelela ngobungqina obungakumbi beenzuzo ezinokuthi zisebenzise iziyobisi ezichasayo. UGqr Brown akazange athathe inxaxheba kuphando lwakutsha nje.
"I-Senolytics ludidi olutsha lweekhompawundi zokulwa nokuguga ezifumaneka kwindalo. Olu phononongo lubonisa ukuba i-PCC1, kunye neekhompawundi ezifana ne-quercetin kunye ne-fisetin, iyakwazi ukubulala ngokukhetha iiseli ze-senescent ngelixa ivumela iiseli ezincinci, eziphilileyo ukuba zigcine ukusebenza kakuhle. ”
"Olu phononongo, njengezinye izifundo kulo mmandla, luvavanye iziphumo zezi zixhobo kwiimpuku kunye nezinye izinto eziphilayo ezisezantsi, umsebenzi omninzi oseleyo phambi kokuba iziphumo zokulwa nokuguga kwezi khompawundi ebantwini zinokumiselwa."
"Ngokuqinisekileyo i-Senolytics ibambe isithembiso sokuba ngamachiza achasene nokuguga ekuphuhliseni," kusho uDkt.
Unjingalwazi u-Ilaria Bellantuono, unjingalwazi wokuguga kwe-musculoskeletal kwiYunivesithi yaseSheffield e-UK, uvumile kudliwano-ndlebe kunye ne-MNT ukuba umbuzo ophambili kukuba ngaba ezi ziphumo zinokuphinda ziphindwe ebantwini. UNjingalwazi uBellantuono naye akazange athathe inxaxheba kwisifundo.
"Olu phononongo longeza kubungqina bokuba ukujolisa kwiiseli ze-senescent kunye neziyobisi ezizibulalayo, ezibizwa ngokuba 'yi-senolytics,' inokuphucula ukusebenza komzimba njengoko sikhula kwaye senze amachiza echemotherapy asebenze ngakumbi kumhlaza."
"Kubalulekile ukuqaphela ukuba yonke idatha kule ndawo ivela kwiimodeli zezilwanyana-kule meko, iimodeli zempuku. Owona mceli mngeni kukuvavanya ukuba la machiza asebenza ngokulinganayo na [ebantwini]. Akukho datha ekhoyo ngeli xesha. ” , kwaye ulingo lwezonyango lusaqala,” watsho uNjingalwazi Bellantuono.
UGqr David Clancy, osuka kwiFakhalthi yeBiomedicine kunye neBiological Sciences kwiYunivesithi yaseLancaster e-UK, uxelele i-MNT ukuba amanqanaba ethamo anokuba ngumcimbi xa usebenzisa iziphumo ebantwini. UDkt Clancy akazange athathe inxaxheba kuphononongo lwakutsha nje.
“Amathamo anikwa iimpuku akholisa ukuba makhulu kakhulu xa kuthelekiswa noko abantu banokukunyamezela. Iidosi ezifanelekileyo ze-PCC1 ebantwini zinokubangela ubutyhefu. Izifundo kwiimpuku zinokuba luncedo; kubonakala ngathi isibindi sabo sitshintsha iziyobisi njengesibindi somntu kunesibindi sempuku. ”
UGqr Richard Siow, umlawuli wophando lokuguga kwiKholeji yaseKing yaseLondon, uxelele i-MNT ukuba uphando lwezilwanyana olungelulo olwabantu lunokuthi lukhokelele kwiziphumo ezilungileyo zeklinikhi ebantwini. UGqr Siow naye akazange athathe inxaxheba kwisifundo.
“Andisoloko ndilinganisa ukufunyanwa kweempuku, iintshulube neempukane nabantu, kuba eyona nto ilula kukuba sinazo ii-akhawunti zebhanki kanti abanazo. Sinazo izipaji, kodwa azinazo. Sinazo nezinye izinto ebomini. Gxininisa ukuba izilwanyana Asinazo: ukutya, unxibelelwano, umsebenzi, iifowuni zeZoom. Ndiqinisekile ukuba iimpuku zinokugxininiswa ngeendlela ezahlukeneyo, kodwa ngokuqhelekileyo sixhalabele ngakumbi ngebhalansi yethu yebhanki, "utshilo uGqr Xiao.
“Ewe, oku kuyahlekisa, kodwa ngokomxholo, yonke into oyifundayo ngeempuku ayinakuguqulelwa ebantwini. Ukuba ubuyimpuku kwaye ufuna ukuphila ukuba ube neminyaka engama-200 ubudala - okanye ilingana nempuku. Kwiminyaka engama-200 ubudala, kuya kuba kuhle, kodwa ngaba iyavakala ebantwini? Oko kusoloko kusisilumkiso xa ndithetha ngophando ngezilwanyana.”
Kwicala elincomekayo, olu luphononongo oluqinileyo olusinika ubungqina obunamandla bokuba uninzi lweendlela zam uphando olugxile kuzo zibalulekile xa sicinga ngobomi ngokubanzi.
"Ingaba imodeli yezilwanyana okanye imodeli yomntu, kunokubakho iindlela ezithile zeemolekyuli ekufuneka sizijonge kumxholo wezilingo zeklinikhi zabantu kunye neekhompawundi ezifana nembewu yomdiliya proanthocyanidins," utshilo uGqr Siow.
UGqr Xiao uthe enye into enokwenzeka kukuphuhlisa isicatshulwa sembewu yomdiliya njengesongezelelo sokutya.
“Ukuba nomzekelo omhle wezilwanyana oneziphumo ezihle [kunye nokupapashwa kwijenali enempembelelo enkulu] ngokwenene kongeza ubunzima kuphuhliso notyalo-mali kuphando lwezonyango lwabantu, enoba luvela kurhulumente, kulingo lwezonyango okanye ngabatyali-mali nakwishishini. Thatha le bhodi yomngeni kwaye ubeke imbewu yeediliya kwiipilisi njengezongezo zokutya ezisekelwe kula manqaku. "
“Isongezo endisithathayo sisenokuba asikhange sivavanywe ngokwezonyango, kodwa iinkcukacha zezilwanyana zibonisa ukuba ziyabongeza ubunzima – nto leyo ekhokelela abathengi ukuba bakholelwe ukuba kukho into ekuso. Yinxalenye yendlela abantu abacinga ngayo ngokutya.” izongezo.” ngeendlela ezithile, oku kuluncedo ekuqondeni ubomi obude,” utshilo uGqr Xiao.
UGqr Xiao ugxininise ukuba umgangatho wobomi bomntu ubalulekile, hayi nje ukuba uphila ixesha elingakanani.
"Ukuba siyakhathala malunga nobude bokuphila kwaye, okona kubaluleke kakhulu, ubude bokuphila, kufuneka sichaze ukuba ubude bokuphila buthetha ntoni. Kulungile ukuba siphila iminyaka eyi-150, kodwa ayilunganga kangako ukuba sichitha iminyaka engama-50 ebhedini. ”
“Ngoko endaweni yokuphila ixesha elide, mhlawumbi ixesha elilunge ngakumbi liya kuba yimpilo nobomi obude: usenokuba wongeza iminyaka kubomi bakho, kodwa ngaba wongeza iminyaka kubomi bakho? Okanye ngaba le minyaka ayinantsingiselo? Kwaye impilo yengqondo: ungaphila iminyaka eyi-130. endala, kodwa ukuba awukwazi ukuyonwabela le minyaka, ngaba kufanelekile?”
“Kubalulekile ukuba sijonge imbono ebanzi yempilo yengqondo kunye nempilo entle, ubuthathaka, iingxaki zokuhamba, indlela esiguga ngayo eluntwini- ingaba akhona amayeza awoneleyo? Okanye ngaba sifuna ngakumbi ukhathalelo lwentlalo? Ukuba sinenkxaso yokuphila kwi-90, i-100 okanye i-110? Ngaba urhulumente unawo umgaqo-nkqubo?”
“Ukuba la mayeza ayasinceda, kwaye sineminyaka engaphezu kwe-100 ubudala, yintoni esinokuyenza ukuze siphucule umgangatho wobomi bethu kunokuba sisebenzise amayeza amaninzi? Apha unembewu yomdiliya, iirharnati, njalo njalo,” watsho uGqr. Xiao. .
Unjingalwazi uBellantuono uthe iziphumo zophononongo ziya kuba luncedo ngakumbi kulingo lwezonyango olubandakanya abaguli abanomhlaza abafumana ichemotherapy.
"Umngeni oqhelekileyo kunye neesenolytics kukugqiba ukuba ngubani oza kuxhamla kubo kunye nendlela yokulinganisa inzuzo kulingo lwezonyango."
Ukongeza, ngenxa yokuba uninzi lwamachiza lusebenza kakhulu ekuthinteleni isifo kunokusinyanga xa sele sifunyenwe, ulingo lwezonyango lunokuthatha iminyaka ngokuxhomekeke kwiimeko kwaye lubiza kakhulu.
“Nangona kunjalo, kule meko, [abaphandi] bachonge iqela lezigulana eliza kuxhamla kulo: abaguli abanomhlaza abafumana ichemotherapy. Ngaphezu koko, kuyaziwa xa ukubunjwa kweeseli ze-senescent kubangelwa (oko kukuthi nge-chemotherapy) kwaye xa "Lo ngumzekelo omhle wesifundo sobungqina bobungqina obunokwenziwa ukuvavanya ukusebenza kwe-senolytics kwizigulane," watsho uNjingalwazi. Bellantuono. ”
Izazinzulu ziye zaphumelela kwaye zikhuselekile ukubuyisela iimpawu zokuguga kwiimpuku ngokuguqula imizila yemfuza kwezinye zeeseli zazo.
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