Kwisifundo esitsha, abaphandi bafumanise ukuba iyeza elitsha elisekelwe kwinxalenye yembewu yediliya linokwandisa ubomi bempuku ngempumelelo.
Olu phononongo, olupapashwe kwiphephancwadi iNature Metabolism, lubeka isiseko sezifundo ezongezelelweyo zeklinikhi ukuze kuqinisekiswe ukuba ezi ziphumo zinokuphinda-phindwa na ebantwini.
Ukwaluphala yinto ephambili ebangela izifo ezininzi ezingapheliyo. Izazinzulu zikholelwa ukuba oku kungenxa yokwaluphala kweeseli. Oku kwenzeka xa iiseli zingasakwazi ukwenza imisebenzi yazo yebhayoloji emzimbeni.
Kwiminyaka yakutshanje, abaphandi bafumanise udidi lwamayeza abizwa ngokuba yi-senolytics. La mayeza anokutshabalalisa iiseli ezisandul’ ukuvela kwilebhu nakwiimodeli zezilwanyana, nto leyo enokunciphisa ukwanda kwezifo ezingapheliyo ezivelayo njengoko sikhula size siphile ixesha elide.
Kolu phononongo, izazinzulu zifumene i-senolytic entsha ethathwe kwinxalenye ye-extract yembewu yediliya ebizwa ngokuba yi-proanthocyanidin C1 (PCC1).
Ngokusekelwe kwidatha yangaphambili, kulindeleke ukuba i-PCC1 ithintele isenzo seeseli ezisandul’ ukufikisa kumanqanaba aphantsi kwaye itshabalalise ngokukhethekileyo iiseli ezisandul’ ukufikisa kumanqanaba aphezulu.
Kwilingo lokuqala, batyhile iimpuku kwiidosi ezingaphantsi kwemitha ezibulalayo ukuze zibangele ukukhula kweeseli. Elinye iqela leempuku emva koko lafumana i-PCC1, kwaye elinye iqela lafumana imoto ephethe i-PCC1.
Abaphandi bafumanise ukuba emva kokuba iimpuku zichatshazelwe yimitha, zavelisa iimpawu zomzimba ezingaqhelekanga, kuquka nobuninzi beenwele ezingwevu.
Unyango lweempuku nge-PCC1 lutshintshe kakhulu ezi mpawu. Iimpuku ezinikwe i-PCC1 nazo zazineeseli ezimbalwa ezisandul’ ukuvela kunye nee-biomarkers ezinxulumene neeseli ezisandul’ ukuvela.
Ekugqibeleni, iimpuku ezikhanyisiweyo zazingasebenzi kakuhle kwaye zinamandla amancinci emisipha. Nangona kunjalo, imeko yatshintsha kwiimpuku ngenxa ye-PCC1, kwaye zazinamazinga aphezulu okusinda.
Kwilingo lesibini, abaphandi bafake i-PCC1 okanye i-vehicle kwiimpuku ezikhulileyo rhoqo emva kweeveki ezimbini kangangeenyanga ezine.
Iqela lifumene inani elikhulu leeseli ezikhulileyo kwizintso, esibindini, emiphungeni nakwiiprostate zeempuku ezindala. Nangona kunjalo, unyango lwe-PCC1 lutshintshe imeko.
Iimpuku ezinyangwe nge-PCC1 zibonise ukuphucuka kwamandla okubamba, isantya esiphezulu sokuhamba, ukunyamezela kokuxhoma, ukunyamezela kokuthambisa i-treadmill, inqanaba lomsebenzi wemihla ngemihla, kunye nokulinganisela xa kuthelekiswa neempuku ezifumene imoto yodwa.
Kwilingo lesithathu, abaphandi bajonge iimpuku ezindala kakhulu ukuze babone indlela i-PCC1 eyichaphazela ngayo ubomi bazo.
Bafumanise ukuba iimpuku ezinyangwe nge-PCC1 ziphila ixesha elide eliyi-9.4% kunoogqirha abanyanga ngemoto.
Ngaphezu koko, nangona bephila ixesha elide, iimpuku ezinyangwe yi-PCC1 azizange zibonakalise ukugula okuphezulu okunxulumene nobudala xa kuthelekiswa neimpuku ezinyangwe yimoto.
Eshwankathela iziphumo, umbhali ohambelanayo uNjingalwazi uSun Yu ovela kwiShanghai Institute of Nutrition and Health eTshayina kunye noogxa bakhe bathi: “Ngoku sinikezela ubungqina bomgaqo wokuba [i-PCC1] inako ukulibazisa kakhulu ukungasebenzi kakuhle okunxulumene nokuguga nokuba ithatyathwe.” kamva ebomini, inamandla amakhulu okunciphisa izifo ezinxulumene nokuguga kunye nokuphucula iziphumo zempilo, ngaloo ndlela ivula iindlela ezintsha zonyango lwabantu abadala kwixesha elizayo ukuphucula impilo kunye nobomi obude.”
UGqr. James Brown, ilungu le-Aston Center for Healthy Aging eBirmingham, e-UK, uxelele iMedical News Today ukuba ezi ziphumo zibonelela ngobungqina obungakumbi ngeenzuzo ezinokubakho zamayeza okulwa nokwaluphala. UGqr. Brown akazange abandakanyeke kolu phando lwakutshanje.
"IiSenolytics ludidi olutsha lweekhompawundi zokulwa nokwaluphala ezifumaneka kakhulu kwindalo. Olu phononongo lubonisa ukuba iPCC1, kunye neekhompawundi ezifana ne-quercetin kunye ne-fisetin, iyakwazi ukubulala iiseli ezisandul' ukuguga ngokuzikhethela ngelixa ivumela iiseli eziselula nezisempilweni ukuba zihlale ziphila kakuhle."
“Olu phononongo, njengezinye izifundo kule ndawo, luhlolisise imiphumo yale mixube kwiimpuku nakwezinye izinto eziphilayo ezisezantsi, ngoko ke kusekho umsebenzi omninzi ngaphambi kokuba iziphumo zokulwa nokwaluphala zale mixube ebantwini zichongwe.”
“I-Senolytics ngokuqinisekileyo inesithembiso sokuba ngamayeza aphambili okulwa nokwaluphala kuphuhliso,” utshilo uGqr. Brown.
UNjingalwazi u-Ilaria Bellantuono, uprofesa wokwaluphala kwemisipha kwiYunivesithi yaseSheffield e-UK, uvumile kudliwanondlebe ne-MNT ukuba umbuzo ophambili kukuba ngaba ezi ziphumo zinokuphinda-phindwa ebantwini. UNjingalwazi uBellantuono naye akazange abandakanyeke kolu phando.
“Olu phononongo longeza kubungqina bokuba ukujolisa kwiiseli ezisandul’ ukufikisa ngamayeza azibulala ngokukhetha, abizwa ngokuba yi-'senolytics,' kunokuphucula ukusebenza komzimba njengoko sikhula kwaye kwenze amayeza e-chemotherapy asebenze ngakumbi kumhlaza.”
“Kubalulekile ukuqaphela ukuba yonke idatha kweli candelo ivela kwiimodeli zezilwanyana—kule meko, iimodeli zeempuku. Umngeni wokwenene kukuvavanya ukuba la mayeza asebenza ngokulinganayo na [kubantu]. Akukho datha ifumanekayo okwangoku.” , kwaye iimvavanyo zeklinikhi ziqala nje,” utshilo uNjingalwazi uBellantuono.
UDkt. David Clancy, ovela kwiSebe lezeMpilo kunye neSayensi yeBhayoloji kwiYunivesithi yaseLancaster e-UK, uxelele i-MNT ukuba amanqanaba edosi anokuba yingxaki xa kusetyenziswa iziphumo ebantwini. UDkt. Clancy akazange abandakanyeke kolu phando lwakutshanje.
"Iidosi ezinikwa iimpuku zihlala zinkulu kakhulu xa kuthelekiswa noko abantu banokukunyamezela. Iidosi ezifanelekileyo ze-PCC1 ebantwini zinokubangela ubuthi. Izifundo ezifunyenwe kwiimpuku zinokuba luncedo; isibindi sazo sibonakala senza amayeza abe nesibindi somntu kunokuba nesibindi sempuku."
UGqr. Richard Siow, umlawuli wophando lokwaluphala kwiKing's College eLondon, uxelele i-MNT ukuba uphando olungengolwabantu kwizilwanyana lusenokungabonisi ziphumo zintle kwezonyango ebantwini. UGqr. Siow naye wayengabandakanyekanga kolu phando.
“Andisoloko ndifanisa ukufunyanwa kweempuku, iimpethu kunye neempukane nabantu, kuba inyani elula kukuba sineeakhawunti zebhanki kwaye azinazo. Sinazo iiwallet, kodwa azinazo. Sinezinye izinto ebomini. Gxininisa ukuba izilwanyana Asinazo: ukutya, unxibelelwano, umsebenzi, iifowuni zeZoom. Ndiqinisekile ukuba iimpuku zinokuxinezeleka ngeendlela ezahlukeneyo, kodwa ngokuqhelekileyo sixhalabele ngakumbi ibhalansi yethu yebhanki,” utshilo uGqr. Xiao.
“Ewe kona, le yintlekisa, kodwa ngokomxholo, yonke into oyifundayo ngeempuku ayinakuguqulelwa ebantwini. Ukuba ubuyimpuku kwaye ufuna ukuphila iminyaka engama-200 ubudala – okanye into efanayo nempuku. Xa uneminyaka engama-200 ubudala, oko bekuya kuba kuhle, kodwa ngaba kuyavakala ebantwini? Oko kuhlala kusisilumko xa ndithetha ngophando lwezilwanyana.”
"Kwelinye icala, olu luphononongo oluqinileyo olusinika ubungqina obuqinileyo bokuba neendlela ezininzi uphando lwam olugxile kuzo zibalulekile xa sicinga ngobomi ngokubanzi."
“Nokuba yimodeli yesilwanyana okanye yeyomntu, kusenokuba kukho iindlela ezithile zeemolekyuli ekufuneka sizijonge kwimeko yovavanyo lwezonyango lwabantu ngeekhompawundi ezifana neeproanthocyanidins zembewu yediliya,” utshilo uGqr. Siow.
UGqr. Xiao uthe enye into enokwenzeka kukuphuhlisa i-extract yembewu yediliya njengesongezelelo sokutya.
"Ukuba nemodeli yezilwanyana elungileyo eneziphumo ezilungileyo [kunye nokupapashwa kwijenali enefuthe elikhulu] kongeza ubunzima kuphuhliso kunye notyalo-mali kuphando lwezonyango lwabantu, nokuba luvela kurhulumente, kuvavanyo lwezonyango okanye ngabatyali-mali nakwimizi-mveliso. Thatha eli bhodi yomngeni kwaye ubeke imbewu yeediliya kwiipilisi njengesongezelelo sokutya ngokusekelwe kula manqaku."
“Esi songezo ndisithathayo sisenokuba asizange sivavanywe ngokwezonyango, kodwa idatha yezilwanyana ibonisa ukuba sonyusa ubunzima – nto leyo ekhokelela abathengi ekubeni bakholelwe ukuba kukho into ekuso. Yinxalenye yendlela abantu abacinga ngayo ngokutya.” izongezo.” ngandlela thile, oku kuluncedo ekuqondeni ubomi obude,” utshilo uGqr. Xiao.
UGqr. Xiao ugxininise ukuba umgangatho wobomi bomntu nawo ubalulekile, kungekuphela nje ukuba uphila ixesha elingakanani.
"Ukuba sikhathalele ixesha lokuphila, kwaye okubaluleke ngakumbi, ixesha lokuphila, kufuneka sichaze ukuba kuthetha ukuthini ixesha lokuphila. Kulungile ukuba siphila de sibe neminyaka eli-150, kodwa akulunganga kangako ukuba sichitha iminyaka engama-50 edlulileyo ebhedini."
"Ngoko endaweni yokuphila ixesha elide, mhlawumbi igama elingcono lingaba yimpilo nokuphila ixesha elide: usenokuba wongeza iminyaka ebomini bakho, kodwa ngaba wongeza iminyaka ebomini bakho? Okanye ngaba le minyaka ayinantsingiselo? Kwaye impilo yengqondo: ungaphila ude ube neminyaka eli-130 ubudala. ubudala, kodwa ukuba awukwazi ukuyonwabela le minyaka, ngaba kufanelekile oko?"
"Kubalulekile ukuba sijonge umbono obanzi wempilo yengqondo kunye nokuphila kakuhle, ubuthathaka, iingxaki zokuhamba, indlela esikhula ngayo kuluntu - ngaba kukho amayeza aneleyo? Okanye ngaba sifuna unyango olongezelelekileyo? Ukuba sinenkxaso yokuphila sifikelele kwiminyaka engama-90, eli-100 okanye eli-110? Ngaba urhulumente unepolisi?"
“Ukuba la mayeza ayasinceda, kwaye sineminyaka engaphezu kwe-100 ubudala, yintoni esinokuyenza ukuphucula umgangatho wobomi bethu kunokuba sithathe nje amayeza amaninzi? Apha unembewu yeediliya, iipomegranate, njl.njl.,” utshilo uGqr. Xiao.
UNjingalwazi uBellantuono uthe iziphumo zolu phononongo ziya kuba luncedo kakhulu kwizilingo zeklinikhi ezibandakanya izigulane zomhlaza ezifumana unyango lwe-chemotherapy.
"Umngeni oqhelekileyo nge-senolytics kukufumanisa ukuba ngubani oza kuzuza kuzo kunye nendlela yokulinganisa inzuzo kwizilingo zeklinikhi."
"Ukongeza, ngenxa yokuba amayeza amaninzi asebenza kakhulu ekuthinteleni isifo endaweni yokusinyanga xa sele sifunyenwe, uvavanyo lweklinikhi lungathatha iminyaka ngokuxhomekeke kwiimeko kwaye luya kubiza kakhulu."
“Nangona kunjalo, kweli tyala, [abaphandi] bachonge iqela lezigulana eziza kuzuza kulo: izigulana ezinomhlaza ezifumana i-chemotherapy. Ngaphezu koko, kuyaziwa ukuba ukwenziwa kweeseli ezisandul’ ukuzalwa kubangelwa nini (oko kukuthi yi-chemotherapy) kwaye xa “Lo ngumzekelo omhle wophando olungqinisisiweyo olunokwenziwa ukuvavanya ukusebenza kwe-senolytics kwizigulana,” utshilo uNjingalwazi uBellantuono.
Izazinzulu ziye zaphumelela kwaye zatshintsha ngokukhuselekileyo iimpawu zokwaluphala kwiimpuku ngokutshintsha iiseli zazo ngokwemfuza.
Uphononongo lweBaylor College of Medicine lufumanise ukuba izongezo zicothisa okanye zilungisa iinkalo zokwaluphala kwendalo kwiimpuku, nto leyo enokwandisa ixesha…
Uphononongo olutsha kwiimpuku kunye neeseli zabantu lufumanise ukuba iikhompawundi zeziqhamo zinokunciphisa uxinzelelo lwegazi. Olu phononongo lukwatyhila nendlela yokufezekisa le njongo.
Izazinzulu zifake igazi leempuku ezindala kwiimpuku eziselula ukuze zijonge isiphumo kwaye zibone ukuba ziyayinciphisa na imiphumo yaso.
Ukutya okulwa nokwaluphala kuya kuthandwa kakhulu. Kweli nqaku sixoxa ngeziphumo zophononongo lwakutshanje lobungqina kwaye sibuze ukuba ngaba kukho naziphi na kwezi…