Ukwaziswa kweCitrus Aurantium

I-Citrus Aurantium, isityalo esikusapho lwe-rutaceae, sisasazeke kakhulu eTshayina. I-Citrus aurantium ligama lemveli laseTshayina lelayimu. Kwimithi yemveli yaseTshayina, i-citrus aurantium sisityalo semveli esisetyenziswa kakhulu ukwandisa ukutya kunye nokulawula i-qi (amandla). E-Itali, i-citrus aurantium ikwaliyeza lemveli ukususela kwinkulungwane ye-16, isetyenziselwa ukunyanga umkhuhlane ofana nemalariya kunye neyeza lokulwa neentsholongwane. Izifundo zakutshanje zibonise ukuba i-citrus aurantium ingathatha indawo ye-ephedra kunyango lokutyeba ngaphandle kwemiphumo emibi yentliziyo.

Izinto ezisebenzayo kwi-citrus aurantium yi-hesperidin, neohesperidin, nobiletin, auranetin, aurantiamarin, nuringin, synephrine, limonin.

Isithako esisebenzayo

i-hesperidin, i-neohesperidin, i-nobiletin, i-D-limonene, i-auranetin, i-aurantiamarin, i-citrin, i-synephrine, i-limonin

Ipropati ebonakalayo

I-crystallization, iqondo lokunyibilika 184-1850C, i-carbonate crystallization 151-152, inyibilika lula emanzini. I-Bitartrate, iqondo lokunyibilika 188-189, inyibilika emanzini, kunzima ukuyinyibilikisa kwi-ethanol, phantse ayinyibiliki kwi-chloroform, i-ether. I-Hydrochloride, ikristale engenambala (i-ethanol-ethyl ether), iqondo lokunyibilika 166-167. I-racemization kulula ukuyenza xa kuhlukaniswa i-chromatography ye-acid enamandla kunye ne-base ion exchange resins.

Impembelelo yezonyango
1. Isiphumo kwisibeleko: I-Fructus Aurantii kunye ne-Fructus Aurantii I-Fructus Decoction evela kwiindawo ezintathu ezahlukeneyo zokuvelisa (iSichuan, iJiangxi, kunye neHunan) ibonise isiphumo sokuthintela isibeleko kwi-vitro yeempuku (ezikhulelweyo nezingakhulelwanga); Isibeleko somvundla sasivuselelwe zombini kwi-vivo nakwi-vitro (ekhulelweyo kwaye engakhulelwanga). I-fistula yesibeleko somvundla nayo ibonakalise ukuba yenza ukuqunjelwa kwesibeleko kube namandla, kwanda uxinzelelo, kwanokuqunjelwa kwe-tetanic. I-tincture ye-Fructus Aurantii kunye ne-Fructus Aurantii fluid extract nazo zinokuvuselela isibeleko somvundla (kwi-vivo nakwi-vitro). Isibeleko sempuku (kwi-vitro) sathintelwa. Into ye-alkaloid ekhutshwe kwi-Fructus Aurantii kunye ne-Lycium orange nayo yayinesiphumo esithile sokuqunjelwa kwisibeleko somvundla kwi-vitro, ngakumbi kwimisipha yesibeleko evuselelwe yi-pituitrin. Inxalenye ye-alkaloid esusiweyo yayinesiphumo sokuphumla kwisibeleko somvundla kwi-vitro, kwaye isiphumo sokuphumla kwesibeleko sasicacile ngakumbi emva kokuvuselwa kwe-hypophysial. I-Cirantin, ekhutshwe kwi-Fructus Aurantii Fructus Peel, ithintela umsebenzi we-hyaluronate ojikeleze isibeleko, nto leyo enokuba inxulumene nefuthe layo lokuthintela ukukhulelwa (ukuthintela ukuchumisa).

2. Impembelelo emathunjini: I-Fructus Aurantii kunye ne-Fructus Aurantii ezivela kwiindawo ezintathu ezahlukeneyo zokuhlala zithintele amathumbu kwiimpuku kunye noonogwaja; Uninzi lweetyhubhu zamathumbu kwiimvukulwana zazithintelwe, kodwa zimbalwa ezazingenalo utshintsho. I-Fructus Aurantii kunye nolwelo lwayo oluphumayo luthintele iityhubhu zamathumbu zeempuku (in vitro) kunye noonogwaja (in vitro). Uxinzelelo oluphezulu (1:1000) luthintele amathumbu amancinci oonogwaja abahlukeneyo kunye neengulube ze-guinea kwaye luthintele imiphumo ye-acetylcholine kunye ne-histamine. Uxinzelelo oluphantsi (1:10 000), emva kwexesha elifutshane lothintelo, lunokubonisa impembelelo yokuvuselela, ubukhulu bomzimba buyanda, kwaye ukuphindaphinda kukhawuleziswe. Kwizinja ezithomalaliswe yi-anesthesia, ubukho bamathumbu buthintelwe ngokucacileyo yi-decoctions. Kodwa kwizinja ezine-gastroenterostomy, inempembelelo ethile yokuvuselela, enokwenza intshukumo yesisu kunye nesingqisho sokuqunjelwa kube namandla.

3. Imiphumo entliziyweni nakwimithambo yegazi: ubungakanani obuncinci bokuvuthuza kunye nomlinganiselo omkhulu wokuthintela intliziyo yexoxo kwi-vitro. I-Fructus Aurantii kunye ne-Fructus Aurantii Aurantii aqueous decoction, i-Fructus Aurantii tincture, kunye ne-fluid extract ziyafana. I-Fructus Aurantii decoction okanye i-alcohol extract efakwe ngaphakathi kwimithambo inokubangela ukonyuka okukhulu koxinzelelo. I-Fructus Aurantii kunye ne-Fructus Aurantii I-Fructus evela kwiindawo ezintathu ezahlukeneyo zokuhlala ibonakaliswe ukuba inemiphumo emincinci ye-vasoconstriction ngokuphuma kwemithambo yegazi yexoxo emzimbeni wonke. Kwizinja ezithomalaliswe yi-anesthesia, bekukho umphumo obalulekileyo nokhawulezayo we-hypertension. Bekungekho kuxinezeleka kokuphefumla okanye uxinzelelo lwegazi olubangelwa yi-epinephrine, kwaye bekungekho kunyuswa okucacileyo kwesantya sentliziyo.

Indlela yokunyusa uxinzelelo inxulumene nezi zinto zilandelayo:

3.1. Ukuvuthuza kwee-receptors ze-α, okubangela ukuxinana kwemithambo yegazi kwamanye amalungu omzimba (i-phenylzoline inokuguqula ukunyuka koxinzelelo ibe yimpendulo yokulwa noxinzelelo lwegazi).

3.2. Ukwanda kokuqiniswa kwentliziyo kunye nokwanda kokuphuma kwentliziyo (ukugeleza kwentliziyo yengulube ye-guinea kunye nokulungiswa kwentliziyo). Emva kwe-reserpine, isiphumo sokunyusa uxinzelelo se-Fructus aurantii aurantii sasibaluleke ngakumbi. Sandise kakhulu ukuhamba kwemithambo yegazi yentliziyo (289.4% kwandise ukuhamba kwemithambo yegazi yentliziyo nge-bubble flowmeter) kwaye sandise ukuhamba kwegazi lobuchopho kunye nezintso nge-86.4% kunye ne-64.5% ngokomndilili, okwahluke kakhulu kwi-norepinephrine. Kwakukho ukwehla kokuhamba kwegazi le-femoral kunye nokunyuka okuncinci kodwa okuncinci kokusetyenziswa kweoksijini yentliziyo, okungahambelani nokunyuka okukhulu kokuhamba kwentliziyo. Kwiimvavanyo ze-ECG kwizinja nakwiingulube ze-guinea, i-arrhythmia (i-ventricular tachycardia okanye i-atrioventricular block) ebangelwa yidosi enkulu ye-aurantii aurantii yayingeyonto imbi. Ngokusekelwe kwiimpawu ezingasentla, kucetyiswa ukuba kunyangwe i-cardiogenic shock. Ii-Alkaloids ezikhutshwe kwi-Fructus Aurantii kunye ne-Lycium orange nazo zinokuphucula okwethutyana uxinzelelo lwemisipha ebushelelezi yemithambo yegazi, ngakumbi xa zinyangwa nge-pituitrin.

4. I-Antithrombotic: Uvavanyo lwe-in vitro lwe-0.1g/ml ye-Fructus Aurantii aqua decoction lubonise isiphumo esicacileyo se-antithrombotic.

5. I-Anti-allergic reaction: I-100mg/kg ye-static pulse injection ye-Fructus Aurantii Aurantii water extract inokuthintela i-passive skin allergy reaction (PCA) kwiimpuku, kwaye i-50μg/ml inokuthintela ukukhululwa kwe-histamine kwiiseli zesisu seempuku.

6. Ezinye iziphumo: I-mycin yesityalo seCitrus inokunciphisa umxholo we-cholestatin kwi-serum kunye nesibindi seempuku ezityiswa ngokutya okune-cholesterol. Isicatshulwa sotywala seFructus Aurantii sasinefuthe lokuthintela isifo sephepha se-mycobacterium H37Rv kwi-vitro, kwaye uxinzelelo lwayo lokuthintela lwaluyi-1:1000. I-decoction yayo yamanzi ayizange ibe nefuthe kwi-guinea pig bronchus. Kuye kwaxelwa ukuba ijusi yeziqhamo ze-citrus inyusa izinga lokubila kwemvubelo kwaye ayinciphisi umsebenzi wayo emva kokubila, ngoko ke ayisiyonto ye-enzyme. Ukusetyenziswa okuphambili kwejusi yeorenji kwezonyango kukuba ityebile kwi-vitamin C kwaye iqulethe inani elikhulu leevithamini A kunye ne-B. Ixolo alina-vitamin C kodwa lityebile kwi-vitamin A. Inencasa ekrakra kwaye inokuqinisa isisu. Abantwana abanjengokuthatha inani elikhulu lee-peels banokubangela ityhefu (intlungu yesisu, ukuqaqamba).

Isalathiso: http://www.a-hospital.com

NgokubaIsicatshulwa se-Citrus Aurantium, nceda unxibelelane nathi. Sikulindele apha nangaliphi na ixesha!!!