Ukuqaliswa kweCitrus Aurantium

ICitrus Aurantium, isityalo sosapho lwe-rutaceae, sisasazwa ngokubanzi eTshayina.I-Citrus aurantium ligama lemveli laseTshayina lekalika.Kwiyeza zesiNtu zaseTshayina, i-citrus aurantium yimifuno yesintu yendabuko esetyenziselwa ukunyusa ukutya kunye nokulawula i-qi (amandla).E-Italiya, i-citrus aurantium ikwaliyeza lesintu ukusukela ngenkulungwane ye-16, isetyenziselwa ukunyanga umkhuhlane onjengemalariya kunye ne-antimicrobial agent.Uphononongo lwakutsha nje lubonise ukuba i-aurantium yesitrasi ingathatha indawo ye-ephedra kunyango lokutyeba ngaphandle kweziphumo ebezingalindelekanga zentliziyo.

I-constituent esebenzayo ye-citrus aurantium yi-hesperidin, neohesperidin, nobiletin, auranetin, aurantiamarin, i-nuringin, i-synephrine, i-limonin.

Isithako esisebenzayo

hesperidin, neohesperidin, nobiletin, D-limonene, auranetin, aurantiamarin, citrin, synephrine, limonin

Izinto eziphathekayo

I-Crystallization, i-melting point 184-1850C, i-carbonate crystallization 151-152, i-soluble kalula emanzini.I-Bitartrate, i-melting point 188-189, i-soluble emanzini, kunzima ukunyibilika kwi-ethanol, phantse i-insoluble kwi-chloroform, i-ether.I-Hydrochloride, i-crystal engenambala (i-ethanol-ethyl ether), i-melting point 166-167.I-racemization kulula ukwenzeka kwi-chromatography yokwahlula i-asidi eqinile kunye nesiseko se-ion exchange resins.

Impembelelo ye-Pharmacological
1. Impembelelo kwi-uterus: I-Fructus Aurantii kunye ne-Fructus Aurantii Fructus Decoction evela kwiindawo ezintathu ezahlukeneyo zokuvelisa (i-Sichuan, i-Jiangxi, ne-Hunan) ibonise umphumo wokuthintela kwi-uterus in vitro yeegundane (ezikhulelweyo nezingakhulelwanga);Isibeleko somvundla sasinemincili zombini kwi-vivo kunye ne-in vitro (ikhulelwe kwaye ingakhulelwanga).I-fistula yesibeleko yomvundla ibonakalise ukuba yenza ukuqhawuka kwesibeleko komelele, ukutsaleka okwandileyo, kunye nokuqhawuka kwe-tetanic.I-tincture ye-Fructus Aurantii kunye ne-Fructus Aurantii fluid isicatshulwa nayo inokuvuyisa isibeleko somvundla (kwi-vivo kunye ne-vitro).Isibeleko sempuku (in vitro) savalwa.Into yealkaloid ebekwe yodwa kwiFructus Aurantii kunye neLycium orange nayo yaba nefuthe elithile lecontractile kwisizalo somvundla kwi-vitro, ngakumbi kwizihlunu zesibeleko ezivuyiswa yipituitrin.Inxalenye ye-alkaloid esusiweyo ibe nefuthe lokuphumla kwisibeleko somvundla kwi-vitro, kwaye umphumo wokuphumla wesibeleko wawucace ngakumbi emva kokuphazamiseka kwe-hypophysial.I-Cirantin, eyedwa kwi-Fructus Aurantii Fructus Peel, inqanda umsebenzi we-hyaluronate malunga ne-ovary, enokuthi ihambelane nefuthe layo lokukhulelwa (ukuthintela ukuchumisa).

2. Impembelelo emathunjini: I-Fructus Aurantii kunye neFructus Aurantii ezivela kwiindawo zokuhlala ezintathu ezahlukeneyo zithintele amathumbu kwiimpuku kunye nemivundla;Uninzi lweetyhubhu zamathumbu kwimivundla zathintelwa, kodwa ezimbalwa zazingenalo utshintsho.I-Fructus Aurantii kunye nesicatshulwa sayo solwelo sinqande iityhubhu zamathumbu eempuku (in vitro) kunye nemivundla (in vitro).Uxinzelelo oluphezulu (1: 1000) luthintele amathumbu amancinci oonogwaja abodwa kunye neengulube ze-guinea kwaye zithintele imiphumo ye-acetylcholine kunye ne-histamine.Ukugxininiswa okuphantsi (1: 10 000), emva kwexesha elifutshane lokuthintela, kunokubonisa umphumo wokuzonwabisa, ukwanda kwe-amplitude, kunye nokukhawuleza ngokukhawuleza.Kwizinja ze-anesthetized, ubukho bamathumbu buvinjelwe ngokucacileyo ngama-decoctions.Kodwa kwizinja ezine-gastroenterostomy, inesiphumo esithile sokuvuselela, esinokwenza intshukumo yesisu kunye nesigqi sokunciphisa sibe namandla.

3. Iimpembelelo kwintliziyo kunye nemithambo yegazi: ixabiso elincinci lokuxhamla kunye nomthamo omkhulu wokuthintela entliziyweni ye-toad in vitro.I-Fructus Aurantii kunye neFructus Aurantii Aurantii i-decoction yamanzi, i-Fructus Aurantii tincture, kunye ne-extract fluid ziyafana.I-decoction ye-Fructus Aurantii okanye i-alcohol extract injected intravenously ingabangela ukuphuculwa okubalulekileyo koxinzelelo.I-Fructus Aurantii kunye ne-Fructus Aurantii Fructus ezivela kwiindawo zokuhlala ezintathu ezohlukeneyo zibonakaliswe ukuba zineempembelelo ezingephi ze-vasoconstriction nge-vascular-vascular perfusion yamasele.Kwizinja ze-anesthetized, kwakukho umphumo obalulekileyo kunye okhawulezayo we-hypertensive.Kwakungekho ukudakumba kokuphefumula okanye i-hypotension ebangelwa yi-epinephrine, kwaye kwakungekho ukwanda okucacileyo kwisantya sentliziyo.

Indlela yokunyusa uxinzelelo inxulumene nezi zinto zilandelayo:

3.1.Ukuvuswa kwee-receptors ze-α, ezibangela i-vasoconstriction kwezinye izitho (i-phenylzoline inokuguqula ukunyusa uxinzelelo kwi-antihypertensive reaction).

3.2.Ukunyanzeliswa kwe-myocardial contraction kunye nokunyuka kwemveliso yenhliziyo (i-guinea pig eyedwa ye-perfusion yentliziyo kunye nokulungiswa kwe-cardiopulmonary).Emva kwe-reserpine, impembelelo yokunyusa uxinzelelo lwe-Fructus aurantii aurantii yayibaluleke kakhulu.Yandisa kakhulu ukuhamba komthambo we-coronary (i-289.4% yandisa ukuhamba komthambo we-coronary nge-bubble flowmeter) kunye nokunyuka kwengqondo kunye nokuhamba kwegazi kwezintso nge-86.4% kunye ne-64.5% ngokuqhelekileyo, eyahluke kakhulu kwi-norepinephrine.Kwakukho ukuncipha kwegazi lomfazi kunye nokunyuka okuncinci kodwa okungabalulekanga kwi-oksijeni ye-myocardial, engazange ihambelane nokunyuka okukhulu kwe-coronary flow.Kwiimvavanyo ze-ECG kwizinja kunye neengulube ze-guinea, i-arrhythmia (i-ventricular tachycardia okanye i-atrioventricular block) ebangelwa umthamo omkhulu we-aurantii aurantii yayingekho nzulu.Ngokusekelwe kwiimpawu ezingentla, kuye kwacetyiswa ukuba kuphathwe ukutshatyalaliswa kwe-cardiogenic.Iialkaloids ezibekwe zodwa kwiFructus Aurantii kunye neLycium orange zisenokonyusa okwexeshana uxinezeleko lwemithambo egudileyo yezihlunu, ngakumbi xa iphathwa ngepituitrin.

4. I-Antithrombotic: Uvavanyo lwe-in vitro ye-0.1g / ml i-Fructus Aurantii aqua decoction ibonise umphumo ocacileyo we-antithrombotic.

5. I-Anti-allergic reaction: I-100mg / kg i-static pulse injection ye-Fructus Aurantii Aurantii isicatshulwa samanzi sinokunqanda ukusabela kwe-skin allergic reaction (PCA) kwiigundane, kunye ne-50μg / ml inokuthintela ukukhululwa kwe-histamine kwiiseli ze-mast zesisu.

6. Ezinye iziphumo: Isityalo seCitrus i-mycin inokunciphisa umxholo we-cholestatin kwi-serum kunye nesibindi seegundane ezondliwa ngokutya okuqukethe i-cholesterol.I-alcohol extract ye-Fructus Aurantii yayinempembelelo yokuthintela kwi-mycobacterium tuberculosis H37Rv in vitro, kwaye i-inhibitory concentration yayiyi-1: 1000.I-decoction yayo yamanzi ayizange ibe nefuthe kwi-guinea pig bronchus.Kuye kwaxelwa ukuba ijusi yeziqhamo zesitrasi yonyusa izinga lokuvubela kwegwele kwaye ayinciphisi umsebenzi wayo emva kokubiliswa, ngoko ayiyonxalenye ye-enzymatic.Eyona nto isetyenziswayo kwezonyango yejusi yeorenji kukuba inevithamin C eninzi kwaye iqulethe A ubuninzi bevithamin A kunye no-B. Ixolo alinayo ivithamin C kodwa lityebile kwivithamin A. Incasa iyakrakra kwaye inokomeleza isisu.Abantwana abanjengokuthatha inani elikhulu leepeel kunokubangela ubuthi (intlungu yesisu, i-cramps).

Isalathiso: http://www.a-hospital.com

KubaCitrus Aurantium Extract, nceda uqhagamshelane nathi.Silinde wena apha nanini na!!!