1. Abachasi be-Endothelin

Ikhutshwe kwi-chamomile ye-herb yaseYurophu, enokumelana ne-endothelin kwaye inqanda ukuveliswa kwee-melanocytes. Ukusabalalisa okungafaniyo kwe-endothelin kwesikhumba yinto ephambili ekhokelela ekubunjweni kwe-pigmentation. Abachasi be-Endothelin banokunqanda i-endothelin .. i-tyrosinase kwaye ikhuthaze ukuhlukana kwee-melanocytes.

Uphononongo lufumene ukuba i-endothelin antagonists ekhutshwe kwizinto eziphilayo zasemanzini zine-cytotoxicity ephantsi kwaye inokuthintela ukuhlukana kwe-endothelin kwi-melanocytes kunye nomsebenzi we-tyrosinase. Izifo ze-Skin hyperpigmentation ezibangelwa ukwanda-inokuba nethuba lokufaka isicelo.

2. I-Resveratrol kunye ne-derivatives yayo

Resveratrolubukhulu becala ikhona kwiidiliya, iPolygonum cuspidatum, iVeratrum kunye nezinye izityalo, kwaye inqanda umsebenzi we-melanocytes kunye nomsebenzi we-tyrosinase ngendlela exhomekeke kugxininiso, ngaloo ndlela inciphisa i-melanin synthesis. U-Jeong et al wafumanisa ukuba ikwanxulunyaniswa neeproteni ezinxulumene ne-tyrosinase kwi-melanogenesis.

UJia Lili kunye nolunye uphononongo lubonise ukuba i-topical resveratrol inokuphucula ngokufanelekileyo umbala wolusu, ibe nefuthe elithile elimhlophe, kwaye ayinazo iimpendulo ezimbi. I-Resveratrol ineziphene zokungazinzi kunye ne-bioavailability embi. Uphononongo lufumene ukuba i-derivatives yayo (i-pentaalkyl ether derivatives kunye ne-tetraester derivatives) ine-bioavailability ephezulu kwaye inokuthintela ngcono ukuhlanganiswa kwe-melanin. Inombono obanzi wokusetyenziswa kwizinto zokuthambisa ezimhlophe.

3. Isicatshulwa seCamellia

ICamellia luhlobo lweCamellia yosapho lweCamellia. Nakamura et al. ifumene ukuba i-camellia flower bud extract inokuthintela ukuveliswa kwe-melanin kwaye ikhuthaze ukuhlukana kwe-fibroblast. U-Huang Xiaofeng kunye nolunye uphando luye lwagqiba ukuba isebe leti ye-Dianshan kunye nesicatshulwa seqabunga lingcono kune-arbutin malunga nokwanda kweeseli kunye nokuvinjelwa komsebenzi we-tyrosinase, kwaye ineempawu ezingcono kune-arbutin. Luhlobo olutsha lwe-ejenti yokucoca ulusu kwaye inoluhlu olubanzi lwezicelo. ithemba.

I-MelaninSynthaseIisithinteli

1. Arbutin

Yinto ebalulekileyo ye-tyrosinase inhibitor, enokuthintela umsebenzi we-tyrosinase, ithintele ukuhlanganiswa kwe-dopa kunye ne-dopaquinone, ngaloo ndlela inqanda ukuveliswa kwe-melanin, kwaye inokunciphisa kakhulu i-pigmentation ebangelwa imitha ye-ultraviolet, kodwa izinzile Ukusebenza kakubi, kunye ezithile. ukusabela kwefoto.

Uphononongo lufumene ukuba i-arbutin ene-concentration ye-3% ineempawu ezintle, i-cytotoxicity ephantsi, ukucaphuka kunye nokwaliwa, kunye nomda ophezulu wokugxininiswa kwayo awukwazi ukudlula i-7%. Uxinzelelo oluphezulu lwe-arbutin luyakwenza ulusu oluqhelekileyo lube nombala. Isithako sayo esisebenzayo sendalo, i-glucopyranoside, inempembelelo enamandla yokuthintela kwi-tyrosinase yabantu kune-arbutin, kwaye ithatha indawo ye-arbutin kuba isebenza ngakumbi kwaye izinzile.

2. I-Licorice Extract

Izinto zayo ezisebenzayo ziyi-liquiritin, i-isoliquiritin kunye ne-licorice flavonoids. I-Liquiritin yenza i-melanin yesikhumba isasazwe ngokulinganayo ngokusasaza i-melanin ehlanganisiweyo, kwaye ifezekisa umphumo wobumhlophe; umsebenzi ophambili we-licorice flavonoids kukuthintela umsebenzi we-tyrosinase, i-DHICA oxidase kunye ne-dopa pigment intermutase.

Uphononongo lufumanise ukuba iimveliso zokhathalelo lwesikhumba zonyango eziqulethe i-licorice extract kunye ne-papain zinokunceda i-melasma kunye ne-post-inflammatory hyperpigmentation, kunye nokusabela okungathandekiyo, kwaye zineempawu ezithile .. kunye .... Ukugxininiswa kwayo kwiimveliso ezimhlophe yi-10% ukuya kwi-40%, kodwa umxholo wezithako ezisebenzayo kwi-licorice awuphezulu kwaye ukucocwa kunzima kwaye kuyabiza.

3. Chuanxiong Extract

Uphononongo lufumene ukuba i-Chuanxiong extract inokuthintela ngokufanelekileyo umsebenzi we-tyrosinase, ebonisa umphumo wokukhuphisana. I-ointment ye-Chuanqiong iphuhliswe ngefomula edibeneyo ye-emulsifiers eyahlukeneyo kunye ne-thickeners eyahlukeneyo, uphando malunga nokusebenza kwayo mhlophe kunye nokusebenza kwabonisa ukuba i-0.5% ~ 1.0% i-Chuanqiong i-ointment ineempawu zokuzinza okulungileyo, ukusebenza okuphezulu kunye nesiphumo esihle sokwenza mhlophe.

4. Rhodiola Rosea Extract

I-salidroside kunye ne-flavonoids yizona nxalenye zayo eziphambili ezisebenzayo, kwaye i-salidroside inokonakalisa i-lipids kunye ne-membrane yeseli ngemitha ye-ultraviolet. I-extract inokuthintela ukuhlanganiswa kwe-melanin kunye nomsebenzi we-tyrosinase, kwaye i-agent esebenzayo emhlophe yesikhumba. Uphononongo lufumene ukuba i-1% kunye ne-5% ye-Rhodiola rosea extract ayizange ibangele ukusabela okubi emzimbeni womntu, kwaye iyisithako esisebenzayo se-cosmetic kunye nokuzinza okuphezulu kwaye inethemba elibanzi kwizicelo zokuthambisa.

5. Aloin

Sisityalo esisezantsi sobunzima bemolekyuli ye-glycoprotein ekhutshwe kwikhala. Ikakhulu inqanda ukubunjwa kwe-dopaquinone ngokuthintela ngokukhuphisanayo indawo ye-dopa oxidation, kwaye ifezekisa inhibeko engakhuphisananga ngokukhuphisana ngokuthintela i-ion zethusi kwindawo ye-hydroxylase. Umsebenzi we-tyrosine hydroxylase. Ukongeza, i-aloin inokunciphisa ubumnyama bolusu olubangelwa yimisebe ye-ultraviolet, kwaye inefuthe elihle lokulungiswa kwesikhumba emva kokuphuma kwelanga. I-Aloin i-hydrophilic kunye ne-non-cytotoxic. Ukuxuba i-aloin kunye ne-arbutin kunokuphucula umphumo wobumhlophe.

6. Izityalo zePolyphenols

Ikakhulu ikhona kwi-bark, iingcambu, amagqabi kunye neziqhamo zezityalo, kwaye umphumo wayo omhlophe uhambelana kakhulu nokufunxa imitha ye-ultraviolet, ukupheliswa kwe-antioxidant ye-radicals yamahhala, kunye nokuvinjelwa kwe-tyrosinase kunye nemisebenzi ye-peroxidase. I-Ellagic acid yi-polyphenol yendalo ekhutshwe kwi-pomegranate peel, i-bark kunye neziqhamo ezahlukeneyo kunye nemifuno. Inokuthintela ukwanda kwe-melanocytes, inqanda umsebenzi we-melanocyte tyrosinase, ukunciphisa i-melanin synthesis, imisebe ye-Ultraviolet inomphumo oqinileyo wokufunxa, onokudlala indima ekukhuseleni ilanga okanye ukukhupha i-radicals yamahhala ngokufunxa imisebe ye-ultraviolet. Isityalo se-polyphenol luhlobo lwesithako esisebenzayo, esinamathuba abanzi ophuhliso kunye nokusetyenziswa kwezithambiso.

Iinkcukacha zoqhagamshelwano:
Shaanxi Ruiwo Phytochem Co.,Ltd.
Umphathi waphesheya: Jason
Isihlwele: 0086-18629669868
I-imeyile:jason@ruiwophytochem.com
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