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UKUBONELELWA KWEFERIKI I-ANISE EXTRACT EPHULEKILEYO YENDALO, I-SHIKIMIC ACID 98%

UKUBONELELWA KWEFERIKI I-ANISE EXTRACT EPHULEKILEYO YENDALO, I-SHIKIMIC ACID 98% Umfanekiso Obonakalayo
  • UKUBONELELWA KWEFERIKI I-ANISE EXTRACT EPHULEKILEYO YENDALO, I-SHIKIMIC ACID 98%

Inkcazo emfutshane:

I-Anise Extract Shikimic Acid, eyimveliso yethu ephambili, enezibonelelo ezininzi kweli candelo:

1, I-Anise yindalo ecocekileyo.

3, I-Shikimic Acid Eyaneleyo iqinisekiswa yi-Whole World Purchase System, iGhana yindawo enye e-Afrika.

3, Izitokhwe zeShikimic Acid ezaneleyo ezineenkcazo zonke, sinexabiso elikhuphisanayo elisekelwe kumgangatho ogqwesileyo, kuba singumzi-mveliso, singumthombo


Iinkcukacha zeMveliso

Ingcaciso yeMveliso

Igama lemveliso:I-Shikimic acid

Udidi:Izicatshulwa zezityalo

Izixhobo ezisebenzayo:I-Shikimic acid

Iinkcukacha zemveliso:98.0%

Uhlalutyo:I-HPLC

Ulawulo lwemeko:Endlwini

Yenza: C7H10O5

Ubunzima beemolekyuli:174.15

Inombolo ye-CAS:138-59-0

Inkangeleko:Umgubo omhlophe onevumba elikhethekileyo.

Ukuchongwa:Uphumelele zonke iimvavanyo zemigangatho

Indawo yokugcina:Gcina kwindawo epholileyo neyomileyo, ivaliwe kakuhle, kude nomswakama okanye ilanga elithe ngqo.

Ukonga Umthamo:Ubonelelo olwaneleyo lwezinto kunye nomjelo ozinzileyo wobonelelo lwezinto ezikrwada.

Intshayelelo ye-Shikimic acid

Yintoni iShikimic Acid?

I-Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) yikhompawundi yendalo eyenzeka ngokwendalo eyinxalenye ebalulekileyo kwi-biosynthesis ye-lignin, ii-amino acids ezinuka kamnandi (i-phenylalanine, i-tyrosine kunye ne-tryptophan), kunye ne-alkaloids ezininzi zezityalo kunye neentsholongwane.

I-Shikimic acid isetyenziswa kakhulu njengesixhobo sokuqala sokwenziwa kweyeza lokulwa nentsholongwane i-oseltamivir (iyeza elilwa ne-H5N1 influenza virus elisetyenziselwa ukunyanga nokuthintela zonke iintlobo ezaziwayo zeentsholongwane zomkhuhlane). Ukwenziwa kwe-(-)-zeylenone okusekelwe kwi-Shikimic Acid kuye kwaxelwa ukuba kusetyenziswa kakhulu njengearhente ye-chemotherapy yomhlaza. Idatha iyafumaneka malunga nokwenziwa kwe-monopalmitoyloxy Shikimic Acid, enomsebenzi we-anticoagulant kwaye ekwaziyo ukunciphisa ukujiya kwegazi xa inikwa nge-intramuscularly. Iqela lophando laseTshayina lenze i-Shikimic Acid derivative, i-triacetyl Shikimic Acid, ebonisa umsebenzi we-anticoagulant kunye ne-antithrombotic.

Ukongeza, izinto eziphuma kwiShikimic Acid zibonakalise umdla omkhulu kwezolimo njengoko uninzi lwazo zisetyenziswa njengemithi yokubulala ukhula kunye nee-antimicrobial agents kuba zinokuvala indlela yeShikimic Acid kwizityalo nakwiibhaktheriya ngaphandle kokuchaphazela kakubi izilwanyana ezanyisayo.

Ngoko ke, iShikimic Acid ingasetyenziswa njenge-reactant yokwenza izinto eziphilayo kwisayensi esisiseko nakwizicelo zonyango kwi-organic chemistry nakwizonyango, ingakumbi ekulungiseleleni amayeza ahlukeneyo.

Njengesixhobo esibalulekileyo sekhemikhali yamayeza, i-shikimic acid ingasetyenziswa kunyango lwezifo ezininzi:

1. Ilwa neentsholongwane kunye nomhlaza

Ngo-1987, izazi zaseJapan zafumanisa ukuba i-analog ye-glyoxalase I inhibitor eyenziwe yi-methyl anthranilate inefuthe elicacileyo lokuthintela kumgca weseli yeHela kunye ne-Escheri ascites carcinoma, inokwandisa ixesha lokusinda kweempuku ezifakwe i-leukemia cell L1210, kwaye ubuthi buphantsi kakhulu, isiphumo sayo sokuthintela sinxulumene kakhulu ne-sulfur hydride reaction. Ngo-1988, izazi zaseTshayina ziye zavelisa i-shikimic acid derivative kwaye zangqina ukuba le compound inefuthe lokuthintela iiseli ze-leukemia L1210 kwi-vitro.

2. I-Anti-thrombosis

Isiphumo se-shikimic acid kunye nezinto eziphuma kuyo kwinkqubo yentliziyo siboniswa kwindima yokulwa ne-thrombosis kunye nokuthintela ukuhlanganiswa kweeplatelet. Uphando lubonisa ukuba: i-shikimic acid inefuthe elinamandla lokuthintela izinga lokuhlanganiswa kweeplatelet zemodeli ye-adenosine diphosphate-induced middle cerebral artery embolism; ukufakwa kwe-shikimic acid ngemithambo yegazi nangemisipha kunokwenza ixesha lokuxinana kwegazi leempuku lihlale ixesha elide.

3. I-Anti-cerebral ischemia

I-Shikimic acid kunye nezinto eziphuma kuyo zinefuthe lokuphucula i-cerebral ischemia, ikakhulu ekunciphiseni umthamo we-cerebral infarction emva kwe-focal cerebral ischemia kwiimpuku, ukunciphisa amanqaku okusebenza kwe-neurological, ukunciphisa izinga le-cerebral edema, ukwandisa ukuhamba kwegazi lobuchopho kwindawo ye-ischemic kunye nezinye izalathisi. Ezinye izifundo zibonise ukuba izinto eziphuma kuyo zinokunciphisa izinga le-erythrocyte aggregation kwaye zithintele ukuhlanganiswa kweeplatelet emva kwe-cerebral ischemia, ngaloo ndlela ziququzelela i-microcirculation ye-cerebral.

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Isatifikethi soHlalutyo

Igama lemveliso I-Shikimic acid Umthombo wezityalo I-Shikimic acid
Ibhetshi NO. I-RW-SA20210322 Ubungakanani beBatch 1100 kgs
Umhla wokwenziwa Meyi. 22. 2021 Umhla WOKUPHELELWA Meyi. 27. 2021
Intsalela yeSolvents Amanzi kunye ne-Ethanol Icandelo Elisetyenzisiweyo Isiqhamo
IZINTO IINKCUKACHA INDLELA ISIPHUMO SOKUVAVANYO
Idatha yePhysical & Chemical
Umbala Mhlophe I-Organoleptic Abafanelekileyo
I-Ordour Uphawu I-Organoleptic Abafanelekileyo
Inkangeleko Umgubo I-Organoleptic Abafanelekileyo
Umgangatho woHlalutyo
Ukuchongwa Ifana nesampulu ye-RS I-HPTLC Iyafana
Uvavanyo ≥98.0% I-HPLC Abafanelekileyo
Ilahleko xa komiswa Ubuninzi be-2.0%. I-Euro.Ph.7.0 [2.5.12] Abafanelekileyo
Uthuthu olupheleleyo Ubuninzi be-0.5%. I-Euro.Ph.7.0 [2.4.16] Abafanelekileyo
isihluzo I-100% idlula nge-80 mesh USP36<786> Ukuvumelana
Intsalela yeSolvents Dibana ne-Euro.Ph.7.0 <5.4> I-Euro.Ph.7.0 <2.4.24> Abafanelekileyo
Intsalela yezibulali-zinambuzane Hlangana neeMfuno ze-USP I-USP36 <561> Abafanelekileyo
Iintsimbi Ezinzima
Iintsimbi Ezinzima Zizonke Ubuninzi be-10ppm. I-Eur.Ph.7.0 <2.2.58> ICP-MS Abafanelekileyo
Inkokeli (Pb) Ubuninzi be-2.0ppm. I-Eur.Ph.7.0 <2.2.58> ICP-MS Abafanelekileyo
I-Arsenic (As) Ubuninzi be-2.0ppm. I-Eur.Ph.7.0 <2.2.58> ICP-MS Abafanelekileyo
I-Cadmium (i-Cd) Ubuninzi be-1.0ppm. I-Eur.Ph.7.0 <2.2.58> ICP-MS Abafanelekileyo
I-Mercury (Hg) Ubuninzi be-1.0ppm. I-Eur.Ph.7.0 <2.2.58> ICP-MS Abafanelekileyo
Uvavanyo lweeMicrobe
Inani Lilonke Leepleyiti I-NMT 1000cfu/g I-USP <2021> Abafanelekileyo
Imvubelo iyonke kunye noMbungu I-NMT 100cfu/g I-USP <2021> Abafanelekileyo
E.Coli Okungalunganga I-USP <2021> Okungalunganga
I-Salmonella Okungalunganga I-USP <2021> Okungalunganga
Ukupakisha kunye nokugcina   Ipakishwe kwiidrama zephepha kunye neengxowa ezimbini zeplastiki ngaphakathi.
NW: 25kgs
Gcina kwisikhongozeli esivalwe kakuhle kude nomswakama, ukukhanya, ioksijini.
Beka ubomi kwishelufa Iinyanga ezingama-24 phantsi kweemeko ezingentla kwaye zikwiphakheji yayo yokuqala.

Umhlalutyi: uDang Wang

Ihlolwe ngu: Lei Li

Ivunyiwe ngu: Yang Zhang

Umsebenzi weMveliso

Isakhiwo seShikimic Acid sithintela ukuhlanganiswa kweeplatelet, sithintela ukwakheka kwe-arterial kunye ne-venous thrombosis kunye ne-cerebral thrombosis; imiphumo yokulwa nokuvuvukala kunye ne-analgesic; Isetyenziswe njengeyeza eliphakathi le-antiviral kunye nelilwa nomhlaza, akufuneki isetyenziswe ngokuthe ngqo.

Isicelo

1, iStar Anise Shikimic Acid isebenzisa i-inhibit platelet aggregation.

2, Ukuthintela i-arterial and venous thrombosis kunye ne-cerebral thrombosis.

3, Amayeza aphakathi okulwa neentsholongwane kunye namayeza okulwa nomhlaza.

4, Iziphumo zokuchasana nokudumba kunye neentlungu.

5, Okwangoku, i-shikimic acid isetyenziswa kakhulu njengenye yezona zinto ziphambili zokwenza unyango lokwenziwa kweyeza lomkhuhlane weentaka-iTamiflu.

6, Izinto zamayeza; Ukutya okusebenzayo kunye nesongezelelo sokutya; Isongezelelo sezithambiso.

KUTHENI UKHETHE US1
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