Yintoni i-Shikimic Acid?

I-asidi ye-Shikimic (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) yinto eyenzeka ngokwemvelo ephilayo ephakathi kwi-biosynthesis ye-lignin, i-amino acids enuka kamnandi (phenylalanine, tyrosine kunye ne-tryptophan), kunye neninzi. isityalo kunye ne-microbial alkaloids.

I-asidi ye-Shikimic isetyenziswa ngokuqhelekileyo njengento yokuqala kwi-industrial synthesis ye-antiviral drug oseltamivir (iyeza elichasayo le-H5N1 lomkhuhlane elisetyenziselwa ukunyanga nokukhusela zonke iintlobo zentsholongwane zomkhuhlane). I-synthesis ye (-) -zeylenone esekelwe kwi-Acid ye-Shikimic kuye kwabikwa ukuba isetyenziswe ngokubanzi njenge-arhente ye-chemotherapy yomhlaza. Idatha ifumaneka kwi-synthesis ye-monopalmitoyloxy Shikimic Acid, enomsebenzi we-anticoagulant kwaye iyakwazi ukunciphisa i-coagulability yegazi xa ilawulwa nge-intramuscularly. Iqela lophando laseTshayina lenze i-shikimic Acid derivative, triacetyl Shikimic Acid, ebonisa umsebenzi we-anticoagulant kunye ne-antithrombotic.

Ukongezelela, i-Shikimic Acid derivatives ibonise umdla omkhulu kwezolimo njengoko uninzi lwazo lusetyenziswa njenge-herbicides kunye ne-antimicrobial agents kuba banokuvala indlela ye-Shikimic Acid kwizityalo kunye neebhaktheriya ngaphandle kokuchaphazela kakubi izilwanyana ezincelisayo.

Ngaloo ndlela, i-Shikimic Acid ingasetyenziselwa njenge-reactant ye-organic synthesis kuzo zombini isayensi esisiseko kunye nezicelo zonyango kwi-organic chemistry kunye neyeza, ngakumbi ukulungiselela iziyobisi ezahlukeneyo.

Njengesixhobo esibalulekileyo samachiza, i-asidi ye-shikimic ingasetyenziswa kunyango lwezifo ezininzi:

1. I-Antibacterial kunye ne-antitumor

Ngo-1987, abaphengululi baseJapan bafumanisa ukuba i-analog ye-glyoxalase I inhibitor eyenziwe yi-methyl anthranilate inempembelelo ecacileyo yokuthintela kwi-Hela cell line kunye ne-Escheri ascites carcinoma, inokwandisa ixesha lokusinda kweempuku ezifakwe kwi-leukemia cell L1210, kwaye ityhefu iphantsi. impembelelo yayo inhibitory ikakhulu ezinxulumene reaction sulphur hydride. Ngo-1988, abaphengululi baseTshayina baye Ngo-1988, abaphengululi baseTshayina baye badibanisa i-shikimic acid derivative kwaye babonisa ukuba le khompawundi inefuthe lokuthintela iiseli ze-leukemia L1210 in vitro.

2. I-Anti-thrombosis

Umphumo we-asidi ye-shikimic kunye ne-derivatives yayo kwi-cardiovascular system iboniswa kwindima ye-anti-thrombosis kunye nokuvinjelwa kwe-platelet aggregation. Uphando lubonisa ukuba: i-asidi ye-shikimic inempembelelo eqinile yokuthintela kwizinga le-platelet aggregation ye-adenosine diphosphate-induced middle cerebral artery embolism model rats; inaliti ye-intravenous kunye ne-intramuscular ye-shikimic acid inokwenza ixesha lokujika kwegazi leempuku libe lide.

3.Anti-cerebral ischemia

I-asidi ye-Shikimic kunye ne-derivatives yayo inempembelelo yokuphucula i-cerebral ischemia, ngokukodwa ekunciphiseni umthamo we-cerebral infarction emva kwe-ischemia ye-cerebral egxininisekile kwiigundane, ukunciphisa inqaku lomsebenzi we-neurological, ukunciphisa iqondo le-cerebral edema, ukwandisa ukuhamba kwegazi kwi-cerebral kwindawo ye-ischemic. kunye nezinye izalathisi. Olunye uphando lubonise ukuba izinto eziphuma kuzo zinganciphisa iqondo le-erythrocyte aggregation kwaye inhibit ukuhlanganiswa kweplatelet emva kwe-cerebral ischemia, ngaloo ndlela iququzelela i-microcirculation ye-cerebral.